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Natural product-derived ferroptosis mediators.
Chen, Yi-Li; Xiong, Lin-An; Ma, Lie-Feng; Fang, Luo; Zhan, Zha-Jun.
Afiliación
  • Chen YL; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
  • Xiong LA; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
  • Ma LF; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
  • Fang L; Department of Pharmacy, Zhejiang Cancer Hospital, PR China. Electronic address: fangluo@zjcc.org.can.
  • Zhan ZJ; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China. Electronic address: zjnpr@zjut.edu.cn.
Phytochemistry ; 219: 114002, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38286199
ABSTRACT
It has been 11 years since ferroptosis, a new mode of programmed cell death, was first proposed. Natural products are an important source of drug discovery. In the past five years, natural product-derived ferroptosis regulators have been discovered in an endless stream. Herein, 178 natural products discovered so far to trigger or resist ferroptosis are classified into 6 structural classes based on skeleton type, and the mechanisms of action that have been reported are elaborated upon. If pharmacodynamic data are sufficient, the structure and bioactivity relationship is also presented. This review will provide medicinal chemists with some effective ferroptosis regulators, which will promote the research of natural product-based treatment of ferroptosis-related diseases in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Ferroptosis Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Ferroptosis Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido