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Iron-related markers of inflammation in horses with colic.
Canola, P A; Salles, R F de; Daneze, E R; Sobreira, M F R; Oliveira, B E de; Favero, M L; Antonioli, M L.
Afiliación
  • Canola PA; Department of Veterinary Medicine and Surgery, São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, São Paulo 14884-900, Brazil. Electronic address: paulo.canola@unesp.br.
  • Salles RF; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
  • Daneze ER; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
  • Sobreira MFR; Centro Universitário Moura Lacerda, Ribeirão Preto, São Paulo, Brazil.
  • Oliveira BE; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
  • Favero ML; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
  • Antonioli ML; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
J Equine Vet Sci ; 134: 105010, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38286193
ABSTRACT
The aim of the study was to compare and correlate levels of ferritin, transferrin, iron and APPs in healthy horses and those surgically treated for strangulating colic. On admission, measurements of inflammatory markers related to iron and total protein, fibrinogen, albumin, haptoglobin and ceruloplasmin were made. The study comprised 22 horses, divided into a control group (CG) of healthy horses (n = 10) and horses with surgically treated acute abdomen (n = 12), obstruction group (OG). The OG was subdivided according to the affected intestinal segment (small vs. large) and according to outcome (survivors vs. non survivors). The OG had higher haptoglobin (34.8±14.2 mg/dL vs 20.8±7.21 mg/dL) and transferrin (487±161 mg/dL vs 369±71.4 mg/dL) values and lower iron (96.9±65 µg/dL vs 218±105 µg/dL) values than the CG. The OG horses with large intestine obstruction had lower values of transferrin (374.6±130 mg/dL) than horses with small intestinal obstruction (598.6±98.9 mg/dL). There was no difference in outcome between horses with large and small intestinal obstruction. Ferritin levels were moderately correlated with total protein (r = 0.594; P = 0.042) and albumin (r = 0.584; P = 0.046) in OG. In the multivariate exploratory analysis, fibrinogen levels were higher in animals that did not survive. In conclusion, haptoglobin, transferrin and iron were useful inflammatory markers for colic in horses. The correlation of ferritin with other APPs shows a possible role of ferritin as an APP in horses. Fibrinogen levels are higher in horses with greater risk of death from strangulating obstructions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cólico / Enfermedades de los Caballos / Obstrucción Intestinal Límite: Animals Idioma: En Revista: J Equine Vet Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cólico / Enfermedades de los Caballos / Obstrucción Intestinal Límite: Animals Idioma: En Revista: J Equine Vet Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos