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Type 2 Diabetes Mellitus and Non-Metastatic Colorectal Cancer: A Retrospective Study on Survival and Toxicity Profiles.
Elabd, Naglaa Said; Alabassy, Mahmoud Magdy; Seddik, Randa Mohamed; Amer, Amany A; Abdelaziz, Reham Ahmed; Sohaib, Ahmed.
Afiliación
  • Elabd NS; Tropical Medicine department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
  • Alabassy MM; General surgery department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
  • Seddik RM; Tropical Medicine department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
  • Amer AA; Tropical Medicine department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
  • Abdelaziz RA; Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
  • Sohaib A; Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Asian Pac J Cancer Prev ; 25(1): 87-94, 2024 Jan 01.
Article en En | MEDLINE | ID: mdl-38285771
ABSTRACT
BACKGROUND AND

AIMS:

Being one of the most common cancers accounting for approximately 185 million cases globally, colorectal cancer (CRC) is one of the leading derivers of cancer-related mortalities. A high prevalence of Type 2 diabetes mellitus and CRC was noted, together with a causal link between diabetes and CRC development. Thereby, the goal of this study was to properly evaluate type 2 Diabetes mellitus in non-metastatic colorectal cancer patients, and to highlight its impacts on patient's outcome.

METHODS:

Patients with non-metastatic colorectal cancer diagnosed between January 2016 and December 2020 were studied retrospectively. Patients were divided into two groups based on whether or not they had type II diabetes. The clinico-pathological, laboratory, treatment and survival data were gathered.

RESULTS:

A total of 318 patients were included in this study. The toxicity of the drugs used in CRC patients receiving the treatment protocols (169 in non-T2DM group and 39 in T2DM group), both groups reported close percentage of side effects and  a similar frequency of drug toxicity occurrence as well as grade of toxicity, with the exception of neuropathy, which was more common in the T2DM group (33.3% vs 11.2%). As for prognosis, non-T2DM and T2DM patients had a mean progression free survival of (71.4 and 60.83 months, respectively) (p = 0.019). Overall survival was 73.1% for T2DM and 85.3% for non T2DM cases. The median overall survival was not reached for both groups in terms of overall survival.

CONCLUSION:

T2DM is considered a risk factor for poor survival among CRC patients. Treatment related toxicity is not affected by the presence or absence of diabetes, yet neuropathy needs further studies for diabetic patients receiving oxaliplatin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Tailandia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Tailandia