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Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model.
Tang, Hao; Xie, Jiang; Du, Yu-Xuan; Tan, Ze-Jiu; Liang, Zhuo-Tao.
Afiliación
  • Tang H; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
  • Xie J; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
  • Du YX; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
  • Tan ZJ; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
  • Liang ZT; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
J Cancer Res Clin Oncol ; 150(2): 48, 2024 Jan 29.
Article en En | MEDLINE | ID: mdl-38285218
ABSTRACT
Osteosarcoma (OS) is the most common malignancy in children and adolescents and has a high probability of recurrence and metastasis. A growing number of studies have shown that neutrophil extracellular traps (NETs) are strongly associated with cancer metastasis, but in osteosarcoma, genes associated with NETs that promote osteosarcoma recurrence and metastasis remain to be explored. We systematically investigated the gene expression patterns of NETs in OS samples from the GEO database. NETs molecular typing was evaluated based on NETs expression profiles, and the association between NETs molecular subtypes and immune microenvironment and metastatic features were explored. Ultimately, we constructed a signature model and column line graph associated with metastasis prediction and screened possible potential drugs for metastatic osteosarcoma. We established two different molecular subtypes of NETs, which showed significant differences in metastatic status, metastasis time, tumor immune microenvironment, and biological effects. We also constructed a NETs-related gene metastasis signature(NRGMS) to assess the expression pattern of NETs in patients to predict metastatic recurrence in osteosarcoma patients. We screened for TOMM40 and FH associated with metastatic recurrence in osteosarcoma patients. Overall, this study constructs a predictive model for osteosarcoma metastasis of NETs-related genes, which is expected to provide new insights into the metastasis of osteosarcoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma / Neoplasias Primarias Secundarias / Trampas Extracelulares Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma / Neoplasias Primarias Secundarias / Trampas Extracelulares Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article Pais de publicación: Alemania