Your browser doesn't support javascript.
loading
Gli1+ Periodontal Mesenchymal Stem Cells in Periodontitis.
Deng, Y; Li, Q; Svoboda, K K H; Opperman, L A; Ruest, L B; Liu, X.
Afiliación
  • Deng Y; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
  • Li Q; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
  • Svoboda KKH; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
  • Opperman LA; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
  • Ruest LB; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
  • Liu X; Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA.
J Dent Res ; 103(3): 279-288, 2024 03.
Article en En | MEDLINE | ID: mdl-38284236
ABSTRACT
Periodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and in tissue repair. However, little is known about how periodontal MSCs in vivo respond under periodontal disease conditions, posing a challenge for periodontium tissue regeneration. In this study, Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model. Our findings show significant changes in the number and contribution of Gli1+ MSCs within the inflamed periodontium. The number of Gli1+ MSCs that contributed to periodontal ligament homeostasis decreased in the periodontitis-induced teeth. While the proliferation of Gli1+ MSCs had no significant difference between the periodontitis and the control groups, more Gli1+ MSCs underwent apoptosis in diseased teeth. In addition, the number of Gli1+ MSCs for osteogenic differentiation decreased during the progression of periodontitis. Following tooth extraction, the contribution of Gli1+ MSCs to the tooth socket repair was significantly reduced in the periodontitis-induced teeth. Collectively, these findings indicate that the function of Gli1+ MSCs in periodontitis was compromised, including reduced contribution to periodontium homeostasis and impaired injury response.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Dent Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Dent Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos