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Role of the Gut Bacteria-Derived Metabolite Phenylacetylglutamine in Health and Diseases.
Krishnamoorthy, Naveen Kumar; Kalyan, Manjunath; Hediyal, Tousif Ahmed; Anand, Nikhilesh; Kendaganna, Pavan Heggadadevanakote; Pendyala, Gurudutt; Yelamanchili, Sowmya V; Yang, Jian; Chidambaram, Saravana Babu; Sakharkar, Meena Kishore; Mahalakshmi, Arehally M.
Afiliación
  • Krishnamoorthy NK; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Kalyan M; Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Hediyal TA; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Anand N; Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Kendaganna PH; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Pendyala G; Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Yelamanchili SV; Department of Pharmacology, College of Medicine, American University of Antigua, P. O. Box W-1451, Saint John's, Antigua and Barbuda.
  • Yang J; Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education and Research, Mysuru 570015, India.
  • Chidambaram SB; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, Nebraska 68198, United States.
  • Sakharkar MK; Department of Genetics, Cell Biology, and Anatomy, UNMC, Omaha, Nebraska 68198, United States.
  • Mahalakshmi AM; Child Health Research Institute, UNMC, Omaha, Nebraska 68198, United States.
ACS Omega ; 9(3): 3164-3172, 2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38284070
ABSTRACT
Over the past few decades, it has been well established that gut microbiota-derived metabolites can disrupt gut function, thus resulting in an array of diseases. Notably, phenylacetylglutamine (PAGln), a bacterial derived metabolite, has recently gained attention due to its role in the initiation and progression of cardiovascular and cerebrovascular diseases. This meta-organismal metabolite PAGln is a byproduct of amino acid acetylation of its precursor phenylacetic acid (PAA) from a range of dietary sources like egg, meat, dairy products, etc. The microbiota-dependent metabolism of phenylalanine produces PAA, which is a crucial intermediate that is catalyzed by diverse microbial catalytic pathways. PAA conjugates with glutamine and glycine in the liver and kidney to predominantly form phenylacetylglutamine in humans and phenylacetylglycine in rodents. PAGln is associated with thrombosis as it enhances platelet activation mediated through the GPCRs receptors α2A, α2B, and ß2 ADRs, thereby aggravating the pathological conditions. Clinical evidence suggests that elevated levels of PAGln are associated with pathology of cardiovascular, cerebrovascular, and neurological diseases. This Review further consolidates the microbial/biochemical synthesis of PAGln and discusses its role in the above pathophysiologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos