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The Free Triiodothyronine, Gamma-Glutamyl Transpeptidase and Spontaneous Bacterial Peritonitis Index: A Novel Model for Predicting 1-Year Mortality in Patients with HBV-Related Hepatic Encephalopathy.
Lin, Lin; Huang, Ze-Yu; Liu, Kai; Tong, Xue-Cheng; Zhang, Zhi-Xin; Xue, Yuan.
Afiliación
  • Lin L; Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
  • Huang ZY; Department of Pharmacy, The Third People's Hospital of Changzhou, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China.
  • Liu K; Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
  • Tong XC; Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
  • Zhang ZX; Department of Infectious Diseases, The Third People's Hospital of Changzhou, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China.
  • Xue Y; Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
Hepat Med ; 16: 1-9, 2024.
Article en En | MEDLINE | ID: mdl-38283915
ABSTRACT
Background and

Aims:

Hepatic encephalopathy (HE) is characterized by neuropsychiatric manifestations in patients with decompensated cirrhosis (DC) and/or liver failure. This study aimed to investigate the predictive value of thyroid hormone in patients with HE.

Methods:

Patients with DC and HE were enrolled, and multivariate logistic analysis was conducted to analyze the risk factors for 1-year mortality.

Results:

Among the 81 patients with HBV-related DC and HE, 9 (11.1%) died within 3 months, and 15 (18.5%) died within the first year. More patients with FT3 < 3.5pmol/L had ascites (33.3% vs 8.9%, P<0.01) and higher model for end-stage liver disease (MELD) (Z=3.669, P<0.01). Additionally, free triiodothyronine (FT3) levels were lower in the non-survivor group (P<0.01). FT3 exhibited a negative correlation with international normalized ratio and MELD (both P<0.05). Multivariate analysis revealed that FT3, gamma-glutamyl transpeptidase (GGT), and spontaneous bacterial peritonitis (SBP) were independent risk factors for 1-year mortality of HE. A new model incorporating FT3, GTT, and SBP demonstrated superiority to MELD based on the AUROC (0.9 and 0.752, P=0.04).

Conclusion:

Low FT3, but not thyroid-stimulating hormone and free tetraiodothyronine, was identified as an independent risk factor for 1-year mortality in patients with DC and HE. The newly proposed prognostic model, which includes FT3, GTT, and SBP, holds significant predictive value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepat Med Año: 2024 Tipo del documento: Article Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepat Med Año: 2024 Tipo del documento: Article Pais de publicación: Nueva Zelanda