Your browser doesn't support javascript.
loading
Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow?
Miljic, Dragana; Pekic, Sandra; Doknic, Mirjana; Stojanovic, Marko; Ilic, Sasa; Djurovic, Marina Nikolic; Jemuovic, Zvezdana; Milojevic, Toplica; Milicevic, Mihailo; Jovanovic, Marija; Medic Stojanoska, Milica; Caric, Bojana; Radic, Nevena; Medenica, Sanja; Manojlovic Gacic, Emilija; Petakov, Milan.
Afiliación
  • Miljic D; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Pekic S; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Doknic M; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Stojanovic M; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Ilic S; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Djurovic MN; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Jemuovic Z; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Milojevic T; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Milicevic M; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Jovanovic M; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Medic Stojanoska M; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Caric B; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Radic N; Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Medenica S; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
  • Manojlovic Gacic E; Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade 11000, Serbia.
  • Petakov M; Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
Endocr J ; 71(3): 285-293, 2024 Mar 28.
Article en En | MEDLINE | ID: mdl-38281757
ABSTRACT
Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -"pure" XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2.24%) with histologically confirmed diagnosis of pituitary XG over the period of 7 years (2015-2021). Patients were further analyzed according to XG etiology "pure"- XG (n = 8) with no identifiable founding lesion were compared to those with histological elements of pituitary tumor or cyst - secondary XG (n = 8). We identified 16 patients (11 male), mean age 44.8 ± 22.3 years, diagnosed with pituitary XG. Secondary forms were associated with Ratke's cleft cyst (RCC, n = 2) and pituitary adenoma (PA, n = 6). The most common presenting features in both groups were hypopituitarism (75%), headache (68.5%) and visual disturbances (37.5%). Predominance of male sex was noted (males 68.75%, females 31.25%), especially in patients with primary forms. Patients with primary pituitary XG were all males (p = 0.0256) and more frequently affected by panhypopituitarism (87.5% vs. 25%, p = 0.0406) compared to patients with secondary causes. Hyperprolactinemia was noted in pituitary tumor group with secondary etiology only (p = 0.0769). Majority of lesions were solid on magnetic resonance imaging - MRI (81.25%). Distinct clinical phenotype was observed dependent on the etiology of XG.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Hipófisis / Neoplasias Hipofisarias / Xantomatosis / Quistes del Sistema Nervioso Central / Quistes Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocr J Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Hipófisis / Neoplasias Hipofisarias / Xantomatosis / Quistes del Sistema Nervioso Central / Quistes Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocr J Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón