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Neurological disorders throughout acute SARS-CoV2 infection: A comparative study between vaccinated and non-vaccinated patients.
Cristillo, Viviana; Pilotto, Andrea; Piccinelli, Stefano Cotti; Libri, Ilenia; Locatelli, Martina; Giunta, Marcello; Mazzoleni, Valentina; Pezzini, Debora; Arici, Davide; Gipponi, Stefano; di Cola, Francesca Schiano; Cottini, Elisabetta; Gamba, Massimo; Magoni, Mauro; Padovani, Alessandro.
Afiliación
  • Cristillo V; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy. Electronic address: viviana.cristillo@gmail.com.
  • Pilotto A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Piccinelli SC; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Libri I; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Locatelli M; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Giunta M; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Mazzoleni V; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Pezzini D; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Arici D; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Gipponi S; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • di Cola FS; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Cottini E; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Gamba M; Stroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili, Spedali Civili Hospital, Brescia, Italy.
  • Magoni M; Stroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili, Spedali Civili Hospital, Brescia, Italy.
  • Padovani A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy.
J Neurol Sci ; 457: 122898, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38281402
ABSTRACT

BACKGROUND:

The role of vaccination on Covid-19 severity in neurological patients is still unknown. We aim at describing clinical characteristics and outcomes of breakthrough and unvaccinated Covid-19 patients hospitalized for neurological disorders.

METHODS:

Two hundred thirty-two Covid-19 patients were admitted to a neuro-Covid Unit form March 1st 2021 to February 28th 2022. Out of the total sample, 74 (32%) were full vaccinated. The prevalence, clinical characteristics, disease severity, expressed by Brescia-COVID Respiratory Severity Scale (BCRSS) and National Early Warning Score 2 (NEWS2), and final outcomes of neurological syndromes were compared between vaccinated and unvaccinated cases. Cox regression analysis was implemented in order to investigate the combined effect of predictors of mortality.

RESULTS:

Breakthrough vaccinated cases were older (years 72.4 ± 16.3 vs 67.0 ± 18.9 years, p = 0.029), showed higher pre-admission comorbidity score and Clinical Frailty scale score (4.46 ± 1.6 vs 3.75 ± 2.0, p = 0.008) with no differences in terms of disease progression or mortality rate (16.2% vs 15.2%), compared to full-dose vaccinated patients. Cox-regression analysis showed age and NEWS2 score as the variables with a significant relation to mortality between the two groups, independently from pre-morbid conditions and inflammatory response.

CONCLUSION:

This study on breakthrough COVID-19 infection could help identify vulnerable neurological patients with higher risk of poor outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Infección Irruptiva / Enfermedades del Sistema Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Infección Irruptiva / Enfermedades del Sistema Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos