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Polygenic Variation Underlying Educational Attainment and Attention-Deficit/Hyperactivity Disorder Indexes Behavior Ratings of Executive Functions in Child Psychiatry Outpatients.
Capawana, Michael R; Vuijk, Pieter J; Martin, Joanna; Pollastri, Alisha R; Forchelli, Gina A; Woscoboinik, Georgia G; Tremblay, Sonia L; Wolfe, Lauren E; Braaten, Ellen B; Doyle, Alysa E.
Afiliación
  • Capawana MR; Massachusetts General Hospital, Boston, MA, USA.
  • Vuijk PJ; Harvard Medical School, Boston, MA, USA.
  • Martin J; Center for Genomic Medicine, MGH, Boston, MA, USA.
  • Pollastri AR; Cardiff University, Cardiff, UK.
  • Forchelli GA; Massachusetts General Hospital, Boston, MA, USA.
  • Woscoboinik GG; Harvard Medical School, Boston, MA, USA.
  • Tremblay SL; Massachusetts General Hospital, Boston, MA, USA.
  • Wolfe LE; Harvard Medical School, Boston, MA, USA.
  • Braaten EB; Center for Genomic Medicine, MGH, Boston, MA, USA.
  • Doyle AE; Center for Genomic Medicine, MGH, Boston, MA, USA.
J Atten Disord ; 28(5): 861-871, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38281105
ABSTRACT

OBJECTIVE:

We leveraged common genetic variation underlying ADHD, educational attainment (EA) and cognition (COG) to understand the nature of the Behavior Rating Inventory for Executive Functions (BRIEF) and its relationship to academic functioning.

METHOD:

Participants were 991 youth, ages 7 to 17, consecutively referred for neuropsychiatric evaluation. Polygenic scores (PGS) for ADHD, EA, and COG were related to the BRIEF using regression analyses. Structural equation models were used to examine the associations between the PGS, BRIEF and academic outcomes (math, reading, and special education services [EDPLAN]).

RESULTS:

After modeling the PGS together, only the EA and ADHD PGS significantly associated with the BRIEF. The BRIEF partially mediated the relationships between EA PGS with math and EDPLAN and fully mediated the relationship between ADHD PGS and EDPLAN.

CONCLUSION:

Genetic data extend evidence that the BRIEF measures a construct relevant to educational success that differs from what is indexed by cognitive testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Psiquiatría Infantil Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Atten Disord Asunto de la revista: PSICOLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Psiquiatría Infantil Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Atten Disord Asunto de la revista: PSICOLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos