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New cassane-type alkaloids and diterpenoids from the pericarps of Caesalpinia bonduc.
Yan, Shuai-Jie; Huang, Si-Yang; Xing, Jia-Shuo; Cai, Yang-Rui; Ruan, Ye-Ping; Zhang, Pan-Pan.
Afiliación
  • Yan SJ; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China.
  • Huang SY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China.
  • Xing JS; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China.
  • Cai YR; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China.
  • Ruan YP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China. Electronic address: 372739049@qq.com.
  • Zhang PP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China. Electronic address: zhangpanpan16@126.com.
Fitoterapia ; 173: 105834, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38280683
ABSTRACT
The phytochemical investigation of the pericarps of Caesalpinia bonduc led to the isolation and identification of five new cassane-type alkaloids caesalminines C - G (1-5) and six new diterpenoids caesalbonducin K - P (6-11), along with seven known compounds (12-18). Compounds 1-5 were identified as a group of rare alkaloids possessing a tetracyclic cassane-type diterpenoid skeleton with a lactam D-ring instead of a typical furan or lactone moiety. The structures of 1-11 were elucidated on the basis of 1D and 2D NMR including HSQC, HMBC, COSY and NOESY, and other spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated in the A431, A549 and U87MG cancer cell lines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caesalpinia / Diterpenos / Alcaloides Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caesalpinia / Diterpenos / Alcaloides Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos