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Hippocampal-prefrontal high-gamma flow during performance of a spatial working memory.
Bai, Wenwen; Liu, Yinglong; Liu, Aili; Xu, Xinyu; Zheng, Xuyuan; Tian, Xin; Liu, Tiaotiao.
Afiliación
  • Bai W; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
  • Liu Y; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
  • Liu A; School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China.
  • Xu X; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
  • Zheng X; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
  • Tian X; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
  • Liu T; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China. Electronic address: liutt@tmu.edu.cn.
Brain Res Bull ; 207: 110887, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38280642
ABSTRACT
Working memory refers to a system that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. The prefrontal cortex (PFC) and hippocampus (HPC) are major structures contributing to working memory. Accumulating evidence suggests that the HPC-PFC interactions are critical for the successful execution of working memory tasks. Nevertheless, the directional information transmission within the HPC-PFC pathway remains unclear. Using simultaneous multi-electrode recordings, we recorded local field potentials (LFPs) from the medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) while the rats performed a spatial working memory task in a Y-maze. The directionality of functional interactions between mPFC and vHPC was assessed using the phase-slope index (PSI). Our findings revealed a frequency-specific oscillatory synchrony in the two regions during the spatial working memory task. Furthermore, an increased high-gamma flow from vHPC to mPFC manifested exclusively during correctly performed trials, not observed during incorrect ones. This suggests that the enhanced high-gamma flow reflects behavioral performance in working memory. Consequently, our results indicate an major role of directional frequency-specific communication in the hippocampal-frontal circuit during spatial working memory, providing a potential mechanism for working memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipocampo / Memoria a Corto Plazo Límite: Animals Idioma: En Revista: Brain Res Bull Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipocampo / Memoria a Corto Plazo Límite: Animals Idioma: En Revista: Brain Res Bull Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos