Split but merge: Golgi fragmentation in physiological and pathological conditions.

Zobaroglu-Özer, Pelin; Bora-Akoglu, Gamze

Zobaroglu-Özer, Pelin; Bora-Akoglu, Gamze.

Afiliación

Zobaroglu-Özer P; Faculty of Medicine, Department of Medical Biology, Hacettepe University, Ankara, Turkey.
Bora-Akoglu G; Faculty of Medicine, Department of Medical Biology, Nigde Ömer Halisdemir University, Nigde, Turkey.

Mol Biol Rep ; 51(1): 214, 2024 Jan 27.

Article en En | MEDLINE | ID: mdl-38280063

ABSTRACT

ABSTRACT

The Golgi complex is a highly dynamic and tightly regulated cellular organelle with essential roles in the processing as well as the sorting of proteins and lipids. Its structure undergoes rapid disassembly and reassembly during normal physiological processes, including cell division, migration, polarization, differentiation, and cell death. Golgi dispersal or fragmentation also occurs in pathological conditions, such as neurodegenerative diseases, infectious diseases, congenital disorders of glycosylation diseases, and cancer. In this review, current knowledge about both structural organization and morphological alterations in the Golgi in physiological and pathological conditions is summarized together with the methodologies that help to reveal its structure.

Asunto(s)

Aparato de Golgi; Enfermedades Neurodegenerativas; Humanos; Aparato de Golgi/metabolismo; Aparato de Golgi/patología; División Celular; Transporte de Proteínas; Enfermedades Neurodegenerativas/metabolismo

Palabras clave

Golgi complex; Golgi fragmentation; Golgi morphology; Golgi structure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Aparato de Golgi Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos

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