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Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis.
Lee, Daniel Junpyo; Kang, An Na; Lee, Junbeom; Kwak, Min-Jin; Mun, Daye; Lee, Daseul; Oh, Sangnam; Kim, Younghoon.
Afiliación
  • Lee DJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea.
  • Kang AN; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea.
  • Lee J; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea.
  • Kwak MJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea.
  • Mun D; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea.
  • Lee D; Agricultural Microbiology Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, Wanju-gun, 55365, Korea.
  • Oh S; Department of Functional Food and Biotechnology, Jeonju University, Jeonju, 55069, Korea. osangnam@jj.ac.kr.
  • Kim Y; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea. ykeys2584@snu.ac.kr.
Commun Biol ; 7(1): 133, 2024 01 26.
Article en En | MEDLINE | ID: mdl-38278957
ABSTRACT
Microbial protein, produced by fermentation of Fusarium venenatum is a promising candidate alternative protein source. Previous study has demonstrated its ability to improve hyperlipidemia in rats, yet the related mechanism remains unclear. In this study, we aimed to evaluate the potential of F. venenatum as an alternative protein source and its impact on lipid metabolism using multi-omics analysis. Initial experiments with Caenorhabditis elegans revealed that F. venenatum enhanced longevity, improved immune responses, and reduced lipid metabolism by downregulating fat synthesis-related genes. Subsequently, we conducted experiments with mice on a high-fat diet to confirm the anti-obesity effects of F. venenatum. The groups fed F. venenatum showed improved lipid profiles and reduced hepatic fat accumulation. Furthermore, fecal metabolomic analysis showed higher excretion of primary bile acid and cholesterol in the groups fed F. venenatum which might lead to a decrease in lipid digestion and hepatic fat accumulation. Collectively, this series of experiments revealed the potential of F. venenatum as a sustainable alternative protein and its application as an anti-obesity supplement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / Fusarium / Multiómica Límite: Animals Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / Fusarium / Multiómica Límite: Animals Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido