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Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.
Rubinstein, Tom; Brickman, Adam M; Cheng, Bin; Burkett, Sandra; Park, Heekuk; Annavajhala, Medini K; Uhlemann, Anne-Catrin; Andrews, Howard; Gutierrez, Jose; Paster, Bruce J; Noble, James M; Papapanou, Panos N.
Afiliación
  • Rubinstein T; Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, New York, New York, USA.
  • Brickman AM; Department of Neurology, Vagelos College of Physicians and Surgeons, New York, New York, USA.
  • Cheng B; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, New York, New York, USA.
  • Burkett S; Department of Biostatistics, Mailman School of Public Health, New York, New York, USA.
  • Park H; Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, New York, New York, USA.
  • Annavajhala MK; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.
  • Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.
  • Andrews H; Division of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and, Surgeons, Irving Medical Center, Columbia University, New York, New York, USA.
  • Gutierrez J; Department of Biostatistics, Mailman School of Public Health, New York, New York, USA.
  • Paster BJ; Department of Neurology, Vagelos College of Physicians and Surgeons, New York, New York, USA.
  • Noble JM; The Forsyth Institute, Cambridge, Massachusetts, USA.
  • Papapanou PN; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Alzheimers Dement ; 20(3): 2191-2208, 2024 03.
Article en En | MEDLINE | ID: mdl-38278517
ABSTRACT

INTRODUCTION:

We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health.

METHODS:

We analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease-related dementia (AD/ADRD).

RESULTS:

In fully adjusted models, having more teeth was associated with lower odds for infarcts, lower white matter hyperintensity (WMH) volume, higher entorhinal cortex volume, and higher cortical thickness. Higher extent of periodontitis was associated with lower entorhinal cortex volume and lower cortical thickness. Differential associations emerged between colonization by specific bacteria/serum antibacterial IgG responses and MRI outcomes.

DISCUSSION:

In an elderly cohort, clinical, microbiological, and serological features of periodontitis were associated with MRI findings related to ADRD risk. Further investigation of causal associations is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Enfermedad de Alzheimer / Envejecimiento Cognitivo Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Enfermedad de Alzheimer / Envejecimiento Cognitivo Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos