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Recent Advancement in Inhaled Nano-drug Delivery for Pulmonary, Nasal, and Nose-to-brain Diseases.
Fu, Qiuxia; Liu, Yangjie; Peng, Cao; Muluh, Tobias Achu; Anayyat, Umer; Liang, Liu.
Afiliación
  • Fu Q; Department of General Medicine, Luzhou People's Hospital, Luzhou 646000, Sichuan China PRC.
  • Liu Y; Department of General Medicine, Luzhou People's Hospital, Luzhou 646000, Sichuan China PRC.
  • Peng C; Department of General Medicine, Luzhou People's Hospital, Luzhou 646000, Sichuan China PRC.
  • Muluh TA; Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
  • Anayyat U; Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
  • Liang L; Department of Pharmacy, Luzhou People's Hospital, Luzhou 646000, Sichuan China PRC.
Curr Drug Deliv ; 2024 Jan 24.
Article en En | MEDLINE | ID: mdl-38275044
ABSTRACT
Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants, intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic medicines have serious adverse effects, necessitating the development of inhaled formulations that allow precise drug delivery to the airways with minimum systemic drug exposure. Particle size, surface charge, biocompatibility, drug capacity, and mucoadhesive are unique chemical and physical features that must be considered for pulmonary and nasal delivery routes due to anatomical and permeability considerations. The traditional management of numerous chronic diseases has a variety of drawbacks. As a result, targeted medicine delivery systems that employ nanotechnology enhancer drug efficiency and optimize the overall outcome are created. The pulmonary route is one of the most essential targeted drug delivery systems because it allows the administering of drugs locally and systemically to the lungs, nasal cavity, and brain. Furthermore, the lungs' beneficial characteristics, such as their ability to inhibit first-pass metabolism and their thin epithelial layer, help treat several health complications. The potential to serve as noninvasive self-administration delivery sites of the lung and nasal routes is discussed in this script. New methods for treating respiratory and some systemic diseases with inhalation have been explored and highlight particular attention to using specialized nanocarriers for delivering various drugs via the nasal and pulmonary pathways. The design and development of inhaled nanomedicine for pulmonary, nasal, and respiratory medicine applications is a potential approach for clinical translation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Drug Deliv Asunto de la revista: FARMACIA / FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Drug Deliv Asunto de la revista: FARMACIA / FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos