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Pharmacokinetic/pharmacodynamic analysis of cephalothin after intramuscular administration in Thoroughbred horses.
Kuroda, Taisuke; Minamijima, Yohei; Niwa, Hidekazu; Mita, Hiroshi; Tamura, Norihisa; Fukuda, Kentaro; Ohta, Minoru.
Afiliación
  • Kuroda T; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
  • Minamijima Y; Laboratory of Racing Chemistry, Tochigi 320-0851, Japan.
  • Niwa H; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
  • Mita H; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
  • Tamura N; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
  • Fukuda K; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
  • Ohta M; Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
J Equine Sci ; 34(4): 111-114, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38274556
ABSTRACT
A pharmacokinetic/pharmacodynamic (PK/PD) approach was used to determine a dosage regimen of cephalothin (CET) after intramuscular (IM) administration in horses. CET plasma concentrations were measured in eight horses after a single IM administration of 11 mg/kg bwt of CET. The data were modeled using a nonlinear mixed-effect model, and the probability of target attainment (PTA) of the PK/PD target was calculated for 5,000 horses generated by Monte Carlo simulations. IM administrations of CET at 11 mg/kg bwt q 8 hr and q 6 hr achieved a PTA of 90% against the MIC90 of S. zooepidemicus and S. aureus, respectively, and were considered to be effective dosage regimens. The total dose for the IM administration recommended in this study was lower than that for intravenous (IV) administration in previous studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Equine Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Equine Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón