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Bone Resorption in Apical Periodontitis Enhanced by Cigarette Smoke Inhalation: Histometric, Immunohistochemical, and Microtomographic Analysis in Rats.
Veiga Vasques, Ana Maria; da Silva, Ana Claudia Rodrigues; Bueno, Carlos Roberto Emerenciano; Duarte, Marco Antonio Hungaro; Ervolino, Edilson; Cintra, Luciano Tavares Angelo; Dezan Junior, Eloi.
Afiliación
  • Veiga Vasques AM; Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, Brazil.
  • da Silva ACR; Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, Brazil.
  • Bueno CRE; Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, Brazil.
  • Duarte MAH; Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Ervolino E; Department of Basic Science, School of Dentistry, São Paulo State University, Araçatuba, Brazil.
  • Cintra LTA; Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, Brazil.
  • Dezan Junior E; Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, Brazil. Electronic address: eloi.dezan@unesp.br.
J Endod ; 50(4): 493-498, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38272443
ABSTRACT

INTRODUCTION:

This study evaluated the effects of cigarette smoke inhalation (CSI) on apical periodontitis (AP) induced in rats by histometric, immunohistochemical, and microtomographic analysis.

METHODS:

A total of 32 male Wistar rats were divided into 4 experimental groups (n = 8) control, CSI, AP, and CSI + AP. Rats in the CSI and CSI + AP groups inhaled cigarette smoke by remaining inside a smoking chamber for 8 minutes 3 times a day for 50 days. After 20 days of smoke inhalation, rats in the AP and CSI + AP groups had the pulp of their first right lower molar exposed to induce AP. Blood was collected on day 50 to evaluate nicotine and serum cotinine levels. The animals' mandibles were removed for histologic processing to evaluate bone resorption by histometric, immunohistochemical (receptor activator of nuclear factor kappa B ligand/osteoprotegerin), and microtomographic analysis. The Student t test was applied.

RESULTS:

Histometric analysis showed a larger area of bone resorption (P < .05) and microtomographic analysis found greater resorption volume (P < .001) for the CSI + AP group compared with the AP group. The CSI + AP group presented a high RANKL immunostaining pattern compared with the AP group (P < .001).

CONCLUSIONS:

CSI increased bone resorption caused by AP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Resorción Ósea / Fumar Cigarrillos Límite: Animals Idioma: En Revista: J Endod Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Resorción Ósea / Fumar Cigarrillos Límite: Animals Idioma: En Revista: J Endod Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos