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Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men.
McQueen, Patrick; Molina, Donald; Pinos, Ivan; Krug, Samuel; Taylor, Anna J; LaFrano, Michael R; Kane, Maureen A; Amengual, Jaume.
Afiliación
  • McQueen P; Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Molina D; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Pinos I; Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Krug S; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
  • Taylor AJ; Carver Metabolomics Core, Roy J. Carver Biotechnology Center, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • LaFrano MR; Carver Metabolomics Core, Roy J. Carver Biotechnology Center, University of Illinois Urbana Champaign, Urbana, IL, USA.
  • Kane MA; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
  • Amengual J; Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL, USA; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA. Electronic address: jaume6@illinois.edu.
J Lipid Res ; 65(3): 100507, 2024 03.
Article en En | MEDLINE | ID: mdl-38272355
ABSTRACT
Finasteride is commonly prescribed to treat benign prostate hyperplasia and male-pattern baldness in cis men and, more recently, trans individuals. However, the effect of finasteride on cardiovascular disease remains elusive. We evaluated the role of finasteride on atherosclerosis using low-density lipoprotein (LDL) receptor-deficient (Ldlr-/-) mice. Next, we examined the relevance to humans by analyzing the data deposited between 2009 and 2016 in the National Health and Nutrition Examination Survey. We show that finasteride reduces total plasma cholesterol and delays the development of atherosclerosis in Ldlr-/- mice. Finasteride reduced monocytosis, monocyte recruitment to the lesion, macrophage lesion content, and necrotic core area, the latter of which is an indicator of plaque vulnerability in humans. RNA sequencing analysis revealed a downregulation of inflammatory pathways and an upregulation of bile acid metabolism, oxidative phosphorylation, and cholesterol pathways in the liver of mice taking finasteride. Men reporting the use of finasteride showed lower plasma levels of cholesterol and LDL-cholesterol than those not taking the drug. Our data unveil finasteride as a potential treatment to delay cardiovascular disease in people by improving the plasma lipid profile.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: J Lipid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: J Lipid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos