Your browser doesn't support javascript.
loading
A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants.
Johnson, Mari; Chelysheva, Irina; Öner, Deniz; McGinley, Joseph; Lin, Gu-Lung; O'Connor, Daniel; Robinson, Hannah; Drysdale, Simon B; Gammin, Emma; Vernon, Sophie; Muller, Jill; Wolfenden, Helen; Westcar, Sharon; Anguvaa, Lazarus; Thwaites, Ryan S; Bont, Louis; Wildenbeest, Joanne; Martinón-Torres, Federico; Aerssens, Jeroen; Openshaw, Peter J M; Pollard, Andrew J.
Afiliación
  • Johnson M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Chelysheva I; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Öner D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • McGinley J; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Lin GL; Biomarkers Infectious Diseases, Janssen Pharmaceutica NV, Beerse, Belgium.
  • O'Connor D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Robinson H; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Drysdale SB; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Gammin E; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Vernon S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Muller J; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Wolfenden H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Westcar S; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Anguvaa L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Thwaites RS; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Bont L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Wildenbeest J; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Martinón-Torres F; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Aerssens J; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
  • Openshaw PJM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford.
  • Pollard AJ; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, United Kingdom.
J Infect Dis ; 229(Supplement_1): S112-S119, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38271230
ABSTRACT

BACKGROUND:

Respiratory syncytial virus (RSV) is a significant cause of infant morbidity and mortality worldwide. Most children experience at least one 1 RSV infection by the age of two 2 years, but not all develop severe disease. However, the understanding of genetic risk factors for severe RSV is incomplete. Consequently, we conducted a genome-wide association study of RSV severity.

METHODS:

Disease severity was assessed by the ReSVinet scale, in a cohort of 251 infants aged 1 week to 1 year. Genotyping data were collected from multiple European study sites as part of the RESCEU Consortium. Linear regression models were used to assess the impact of genotype on RSV severity and gene expression as measured by microarray.

RESULTS:

While no SNPs reached the genome-wide statistical significance threshold (P < 5 × 10-8), we identified 816 candidate SNPs with a P-value of <1 × 10-4. Functional annotation of candidate SNPs highlighted genes relevant to neutrophil trafficking and cytoskeletal functions, including LSP1 and RAB27A. Moreover, SNPs within the RAB27A locus significantly altered gene expression (false discovery rate, FDR P < .05).

CONCLUSIONS:

These findings may provide insights into genetic mechanisms driving severe RSV infection, offering biologically relevant information for future investigations.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child / Humans / Infant Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child / Humans / Infant Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos