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Plasmonic biochips with enhanced stability in harsh environments for the sensitive detection of prostate-specific antigen.
Yeh, I-Hsiu; Shi, Hui-Fang; Darius, Evan; Lien, Mei-Chin; Lu, Yin-Cheng; Wang, Congzhou; Liu, Keng-Ku.
Afiliación
  • Yeh IH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. kkliu@mx.nthu.edu.tw.
  • Shi HF; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. kkliu@mx.nthu.edu.tw.
  • Darius E; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. kkliu@mx.nthu.edu.tw.
  • Lien MC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. kkliu@mx.nthu.edu.tw.
  • Lu YC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. kkliu@mx.nthu.edu.tw.
  • Wang C; Nanoscience and Biomedical Engineering, South Dakota School of Mines and Technology, Rapid City, South Dakota 57701, USA.
  • Liu KK; BioSystems Networks & Translational Research (BioSNTR), Rapid City, South Dakota 57701, USA.
J Mater Chem B ; 12(6): 1617-1623, 2024 Feb 07.
Article en En | MEDLINE | ID: mdl-38270244
ABSTRACT
Hollow and porous plasmonic nanomaterials have been demonstrated for highly sensitive biosensing applications due to their distinctive optical properties. Immunosensors, which rely on antibody-antigen interactions, are essential constituents of diverse biosensing platforms owing to their exceptional binding affinity and selectivity. The majority of immunosensors and conventional bioassays needs special storage conditions and cold chain systems for transportation. Prostate-specific antigen (PSA), a serine protease, is widely employed in the diagnosis of prostate cancer. In this study, we present the successful utilization of a biopolymer-preserved plasmonic biosensor with improved environmental stability for the sensitive detection of PSA. The preserved plasmonic biosensors exhibited sustained sensitivity in the detection of PSA, achieving a limit of detection of 10 pg mL-1. Furthermore, these biosensors exhibited remarkable stability at elevated temperatures for one week.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Técnicas Biosensibles / Nanoestructuras Tipo de estudio: Diagnostic_studies Límite: Humans / Male Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Técnicas Biosensibles / Nanoestructuras Tipo de estudio: Diagnostic_studies Límite: Humans / Male Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido