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Aged oolong tea alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and its metabolites.
Wu, Jun; Deng, Xuming; Sun, Yue; Li, Jing; Dai, Haomin; Qi, Siyu; Huang, Yan; Sun, Weijiang.
Afiliación
  • Wu J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Deng X; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Sun Y; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Li J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Dai H; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Qi S; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Huang Y; Anxi College of Tea Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Sun W; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Food Chem X ; 21: 101102, 2024 Mar 30.
Article en En | MEDLINE | ID: mdl-38268839
ABSTRACT
In this study, the mechanism of aged oolong tea (AOT) to alleviate colitis was investigated in terms of microbiome, metabolome, and fecal microbiota transplantation (FMT). AOT storage period could alleviate colitis in mice and there were some differences in AOT between storage periods, especially AOT-10. AOT improves UC by modulating oxidative stress and inflammatory factors and upregulating intestinal tight junction protein expression (Occludin, Claudin-1, ZO-1 and MUC2), which is associated with the recovery of gut microbiota. FMT and targeted metabolomics further demonstrate that the anti-inflammatory effects of AOT can reshape the gut microbiota through faecal bacterial transfer. Anti-inflammatory effects are exerted through the stimulation of metabolic pathways associated with amino acid, fatty acid and bile acid metabolites. Importantly, the study identified key bacteria (e.g., Sutterella, Clostridiaceae_Clostridium, Mucispirillum, Oscillospira and Ruminococcus) for the development and remission of inflammation. Conclusively, AOT may have great potential in the future adjuvant treatment of colitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Food Chem X Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Food Chem X Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos