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Differential recruitment of brain circuits during fear extinction in non-stressed compared to stress resilient animals.
Pearson-Leary, Jiah; Abramenko, Alexander P; Estela-Pro, Valerie; Feindt-Scott, Elizabeth; Yan, Jason; Vigderman, Abigail; Luz, Sandra; Bangasser, Debra; Ross, Richard; Kubin, Leszek; Bhatnagar, Seema.
Afiliación
  • Pearson-Leary J; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Abramenko AP; Department of Biology, Haverford College, Haverford, PA, USA.
  • Estela-Pro V; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Feindt-Scott E; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Yan J; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Vigderman A; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Luz S; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Bangasser D; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
  • Ross R; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kubin L; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bhatnagar S; Stress Neurobiology Center, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA. bhatnagars@chop.edu.
Sci Rep ; 14(1): 2125, 2024 01 25.
Article en En | MEDLINE | ID: mdl-38267506
ABSTRACT
Dysfunctional fear responses in post-traumatic stress disorder (PTSD) may be partly explained by an inability to effectively extinguish fear responses elicited by trauma-related cues. However, only a subset of individuals exposed to traumatic stress develop PTSD. Therefore, studying fear extinction deficits in animal models of individual differences could help identify neural substrates underlying vulnerability or resilience to the effects of stress. We used a rat model of social defeat in which rats segregate into passively and actively coping rats. In previous work, we showed that passively coping rats exhibit disruptions in social interaction whereas actively coping rats do not display behaviors differently from controls, indicating their resilience. Here, adult male rats exposed to 7 days of social defeat were tested for fear extinction, retention of extinction, and persistence of retention using contextual fear and ethologically-relevant fear tests. Passively coping rats exhibited elevated freezing in response to the previously extinguished context. Analyses of cFos expressing cells across select brain regions showed high correlations within dorsal hippocampal subregions, while passively coping rats had high correlations between the dorsal hippocampus CA1 and the central and basolateral subregions of the amygdala. Importantly, although control and actively coping rats showed similar levels of behavioral extinction, there was little similarity between activated structures, suggesting stress resilience in response to chronic social defeat involves an adaptive differential recruitment of brain circuits to successfully extinguish fear memories.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resiliencia Psicológica Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resiliencia Psicológica Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido