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Polystyrene nanoplastics induced size-dependent developmental and neurobehavioral toxicities in embryonic and juvenile zebrafish.
Chen, Jiangfei; Liang, Qiuju; Zheng, Yi; Lei, Yuhang; Gan, Xiufeng; Mei, He; Bai, Chenglian; Wang, Haiyan; Ju, Jingjuan; Dong, Qiaoxiang; Song, Yang.
Afiliación
  • Chen J; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China; Wenzhou Municipal Key Laboratory of Neurodevelopmen
  • Liang Q; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Zheng Y; School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Lei Y; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Gan X; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Mei H; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Bai C; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Wang H; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Ju J; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China; Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, Wenzhou Medical University, Wenzhou, 325035, PR China.
  • Dong Q; School of Public health, Wenzhou Medical University, Wenzhou 325035, PR China.
  • Song Y; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China. Electronic address: yangsong@rcees.ac.cn.
Aquat Toxicol ; 267: 106842, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38266469
ABSTRACT
Because of widespread environmental contamination, there is growing concern that nanoplastics may pose a risk to humans and the environment. Due to their small particle size, nanoplastics may cross the blood-nerve barrier and distribute within the nervous system. The present study systematically investigated the uptake/distribution and developmental/neurobehavioral toxicities of different sizes (80, 200, and 500 nm) of polystyrene nanoplastics (PS) in embryonic and juvenile zebrafish. The results indicate that all three sizes of PS could cross the chorion, adsorb by the yolk, and distribute into the intestinal tract, eye, brain, and dorsal trunk of zebrafish, but with different patterns. The organ distribution and observed developmental and neurobehavioral effects varied as a function of PS size. Although all PS exposures induced cell death and inflammation at the cellular level, only exposures to the larger PS resulted in oxidative stress. Meanwhile, exposure to the 80 nm PS increased the expression of neural and optical-specific mRNAs. Collectively, these studies indicate that early life-stage exposures to PS adversely affect zebrafish neurodevelopment and that the observed toxicities are influenced by particle size.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos