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Self-focused brain predictors of cognitive behavioral therapy response in a transdiagnostic sample.
Fang, Angela; Baran, Bengi; Feusner, Jamie D; Phan, K Luan; Beatty, Clare C; Crane, Jessica; Jacoby, Ryan J; Manoach, Dara S; Wilhelm, Sabine.
Afiliación
  • Fang A; Department of Psychology, University of Washington, Seattle, WA, 98195-1525, USA. Electronic address: angfang@uw.edu.
  • Baran B; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242-1407, USA.
  • Feusner JD; Centre for Addiction and Mental Health, Brain Imaging Health Center, Ontario, Toronto, Canada, M5T1R8; Department of Psychiatry, University of Toronto, Ontario, Toronto, Canada, M5T1R8; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
  • Phan KL; Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, OH, 43210-1240, USA.
  • Beatty CC; Department of Psychology, Stony Brook University, Stony Brook, NY, 11794-2500, USA.
  • Crane J; Department of Psychology, University of Washington, Seattle, WA, 98195-1525, USA.
  • Jacoby RJ; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114-2696, USA.
  • Manoach DS; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114-2696, USA; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, 02129-2020, USA.
  • Wilhelm S; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114-2696, USA.
J Psychiatr Res ; 171: 108-115, 2024 03.
Article en En | MEDLINE | ID: mdl-38266332
ABSTRACT

BACKGROUND:

Effective biomarkers of cognitive behavioral therapy (CBT) response provide information beyond available behavioral or self-report measures and may optimize treatment selection for patients based on likelihood of benefit. No single biomarker reliably predicts CBT response. In this study, we evaluated patterns of brain connectivity associated with self-focused attention (SFA) as biomarkers of CBT response for anxiety and obsessive-compulsive disorders. We hypothesized that pre-treatment as well as pre-to post-treatment changes in functional connectivity would be associated with improvement during CBT in a transdiagnostic sample.

METHODS:

Twenty-seven patients with primary social anxiety disorder (n = 14) and primary body dysmorphic disorder (n = 13) were scanned before and after 12 sessions of CBT targeting their primary disorder. Eligibility was based on elevated trait SFA scores on the Public Self-Consciousness Scale. Seed-based resting state functional connectivity associated with symptom improvement was computed using a seed in the posterior cingulate cortex of the default mode network.

RESULTS:

At pre-treatment, stronger positive connectivity of the seed with the cerebellum, and stronger negative connectivity with the putamen, were associated with greater clinical improvement. Between pre-to post-treatment, greater anticorrelation between the seed and postcentral gyrus, extending into the inferior parietal lobule and precuneus/superior parietal lobule was associated with clinical improvement, although this did not survive thresholding.

CONCLUSIONS:

Pre-treatment functional connectivity with the default mode network was associated with CBT response. Behavioral and self-report measures of SFA did not contribute to predictions, thus highlighting the value of neuroimaging-based measures of SFA. CLINICAL TRIALS REGISTRATION ClinicalTrials.gov Identifier NCT02808702 https//clinicaltrials.gov/ct2/show/NCT02808702.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Terapia Cognitivo-Conductual Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Terapia Cognitivo-Conductual Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido