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Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy
Poodineh, Jafar; Akhlaghpour, Azimeh; Ghaedrahmati, Farhoodeh; Khojasteh Pour, Fatemeh; Uddin, Shahab; Farzaneh, Maryam; Azizidoost, Shirin.
Afiliación
  • Poodineh J; Department of Clinical Biochemistry, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Akhlaghpour A; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
  • Ghaedrahmati F; Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Khojasteh Pour F; Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Uddin S; Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
  • Farzaneh M; Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Azizidoost S; Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Stem Cell Res Ther ; 2024 01 23.
Article en En | MEDLINE | ID: mdl-38265390
ABSTRACT
Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal and differentiation capabilities, making them a potential therapeutic target for effective PCa treatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research has shown that various signaling pathways, such as Notch, SHH, TGF-ß, Wnt, STAT3, AKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally, non-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators of PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could offer new opportunities for the management of PCa. This review summarizes the current knowledge surrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Stem Cell Res Ther Asunto de la revista: TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Stem Cell Res Ther Asunto de la revista: TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos