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The Clinical Behavior and Recurrence Patterns of Oral Cavity Cancer in Oral Lichen Planus Patients.
Yosefof, Eyal; Kurman, Noga; Edri, Nofar; Rosenfeld, Eli; Bachar, Gideon; Shpitzer, Thomas; Yehuda, Moshe; Mizrachi, Aviram; Najjar, Esmat.
Afiliación
  • Yosefof E; Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
  • Kurman N; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Edri N; Institute of Oncology, Davidoff Center, Rabin Medical Center, Petach Tikva, Israel.
  • Rosenfeld E; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Bachar G; Institute of Oncology, Davidoff Center, Rabin Medical Center, Petach Tikva, Israel.
  • Shpitzer T; Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
  • Yehuda M; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Mizrachi A; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Najjar E; Department of Maxillofacial Surgery, Rabin Medical Center, Petach Tikva, Israel.
Laryngoscope ; 134(7): 3146-3151, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38265161
ABSTRACT

OBJECTIVES:

Oral lichen planus (OLP) is a chronic inflammatory disorder involving epithelia with squamous differentiation. Although described as a potential malignant precursor, the characteristics of malignancies arising among these patients are not widely described. Our goal was to describe the patterns of disease recurrence of patients with oral cavity squamous cell carcinoma (OSCC) arising on the background of OLP.

METHODS:

A retrospective analysis of all surgically treated patients with OSCC at a university-affiliated tertiary care center between 2000 and 2020.

RESULTS:

Two hundred seventy-nine patients with OSCC treated surgically were included. Forty (14.3%) had OLP. The mean age of patients with OLP was 70.9 years compared with 64.3 years for non-OLP patients (p = 0.03). OLP patients had a significantly higher rate of disease recurrence, persistence, or multiple primary disease (70% vs. 33.9%, p < 0.001). The mean number of sequential oncologic events for each patient with recurrence was also significantly higher among OLP patients (1.86 vs. 1.36, p = 0.03), a difference explained by a higher rate of multiple primary presentations (0.71 vs. 0.28, p = 0.008). A significant difference in disease-free survival (DFS) was demonstrated between the groups as patients with OLP had a lower 5-year DFS (34.7% vs. 61.3%, log-rank p value <0.001). On multivariate analysis, OLP was significantly associated with multiple primary events (p < 0.001, Odds ratio = 7.42, 95% confidence interval 2.9-19).

CONCLUSIONS:

OSCC patients with OLP background demand close clinical follow-up, as multiple primary disease is significantly more common and the DFS is significantly lower among these patients. A thorough clinical evaluation for all oral cavity subsites is mandatory. LEVEL OF EVIDENCE 3 Laryngoscope, 1343146-3151, 2024.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Liquen Plano Oral / Recurrencia Local de Neoplasia Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Laryngoscope Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Liquen Plano Oral / Recurrencia Local de Neoplasia Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Laryngoscope Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos