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Utility of 68Ga-DOTATATE PET-MRI for Gamma Knife® stereotactic radiosurgery treatment planning for meningioma.
Ratnayake, Gishan; Huo, Michael; Mehta, Akash; Ramachandran, Prabhakar; Pinkham, Mark B; Law, Phillip; Watkins, Trevor; Olson, Sarah; Hall, Bruce; Brown, Simon; Lusk, Ryan; Jones, Catherine; O'Mahoney, Eoin; McGill, George; Foote, Matthew C.
Afiliación
  • Ratnayake G; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Huo M; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Mehta A; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Ramachandran P; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Pinkham MB; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Law P; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Watkins T; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Olson S; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Hall B; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Brown S; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Lusk R; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • Jones C; Department of Medical Imaging, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • O'Mahoney E; Faculty of Medicine, University of Queensland, Brisbane 4006, Australia.
  • McGill G; Department of Medical Imaging, Princess Alexandra Hospital, Brisbane 4102, Australia.
  • Foote MC; Department of Medical Imaging, Princess Alexandra Hospital, Brisbane 4102, Australia.
Br J Radiol ; 97(1153): 180-185, 2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38263827
ABSTRACT

OBJECTIVES:

To investigate the impact of adding 68Ga-DOTATATE PET/MRI to standard MRI for target volume delineation in Gamma Knife® stereotactic radiosurgery (GKSRS) for meningioma.

METHODS:

Seventeen patients with 18 lesions undergoing GKSRS for WHO grade 1 meningioma were enrolled in a prospective study. All patients underwent pre-treatment 68Ga-DOTATATE PET/MRI examination in addition to standard procedures. Five clinicians independently contoured the gross tumour volume (GTV) based on standard MRI (GTVMRI) and PET/MRI (GTVPET/MRI) on separate occasions. Interobserver agreement was evaluated using Cohen's Kappa statistic (CKS), Dice similarity coefficient (DC), and Hausdorff distance (HD). Statistical analysis was performed with paired t-test and Wilcoxon signed rank test.

RESULTS:

The addition of PET/MRI significantly increased GTV contour volume (mean GTVPET/MRI 3.59 cm3 versus mean GTVMRI 3.18 cm3, P = .008). Using the treating clinician's pre-treatment GTVMRI as the reference, median CKS (87.2 vs 77.5, P = .006) and DC (87.2 vs 77.4, P = .006) were significantly lower, and median HD (25.2 vs 31.0, P = .001) was significantly higher with the addition of PET/MRI. No significant difference was observed in interobserver contouring reproducibility between GTVMRI and GTVPET/MRI.

CONCLUSION:

The addition of 68Ga-DOTATATE PET/MRI for target volume delineation in GKSRS for meningioma is associated with an increase in GTV volume and greater interobserver variation. PET/MRI did not affect interobserver contouring reproducibility. ADVANCES IN KNOWLEDGE This study provides novel insights into the impact of 68Ga-DOTATATE PET/MRI on GTV delineation and interobserver agreement in meningioma GKSRS, highlighting its potential for improving GKSRS treatment accuracy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Radiocirugia / Neoplasias Meníngeas / Meningioma Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Br J Radiol Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Radiocirugia / Neoplasias Meníngeas / Meningioma Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Br J Radiol Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido