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Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry.
van Hal, Tamara W; van den Reek, Juul M P A; Wenink, Mark H; Otero, Marisol E; Ossenkoppele, Paul M; Njoo, Marcellus D; Oostveen, Annet; Peters, Bas; Tjioe, Milan; Kop, Else N; Körver, John E M; Dodemont, Sharon R P; Kleinpenning, Marloes M; Berends, Maartje A M; Veldkamp, Wendelien R; van Doorn, Martijn B A; Mommers, Johannes M; Lindhout, Robert-Jan; Kuijpers, Astrid L A; van Lümig, Paula P; de Jonge, C Els J; Tupker, Ron A; Hendricksen, Judith; Keijsers, Romy R; van den Hoogen, Frank H J; Vriezekolk, Johanna E; de Jong, Elke M G J.
Afiliación
  • van Hal TW; Department of Rheumatology, Sint Maartenskliniek, Nijmegen, the Netherlands.
  • van den Reek JMPA; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Wenink MH; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Otero ME; Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Ossenkoppele PM; Department of Rheumatology, Sint Maartenskliniek, Nijmegen, the Netherlands.
  • Njoo MD; Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Oostveen A; Department of Dermatology, ZiekenhuisGroep Twente, Almelo/Hengelo, the Netherlands.
  • Peters B; Department of Dermatology, ZiekenhuisGroep Twente, Almelo/Hengelo, the Netherlands.
  • Tjioe M; Department of Dermatology, Gelre Ziekenhuizen, Apeldoorn, the Netherlands.
  • Kop EN; Department of Dermatology, Ziekenhuis Rijnstate, Arnhem, the Netherlands.
  • Körver JEM; Department of Dermatology/DermaTeam, Bravis Ziekenhuis, Bergen op Zoom, the Netherlands.
  • Dodemont SRP; Department of Dermatology, Bernhoven Ziekenhuis, Uden, the Netherlands.
  • Kleinpenning MM; Department of Dermatology, Amphia Ziekenhuis, Breda, the Netherlands.
  • Berends MAM; Department of Dermatology, Catharina Ziekenhuis, Eindhoven, the Netherlands.
  • Veldkamp WR; Department of Dermatology, Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
  • van Doorn MBA; Department of Dermatology, Slingeland Ziekenhuis, Doetinchem, the Netherlands.
  • Mommers JM; Department of Dermatology, Ziekenhuis Gelderse Vallei, Ede, the Netherlands.
  • Lindhout RJ; Department of Dermatology, ErasmusMC, Rotterdam, the Netherlands.
  • Kuijpers ALA; Department of Dermatology, St. Anna Ziekenhuis, Geldrop, the Netherlands.
  • van Lümig PP; Department of Dermatology, Jeroen Bosch Ziekenhuis, 's Hertogenbosch, the Netherlands.
  • de Jonge CEJ; Department of Dermatology, Maxima Medisch Centrum, Eindhoven, the Netherlands.
  • Tupker RA; Department of Dermatology, Maastricht UMC+, Maastricht, the Netherlands.
  • Hendricksen J; Department of Dermatology, UMC Utrecht, Utrecht, the Netherlands.
  • Keijsers RR; Department of Dermatology, Sint Antoniusziekenhuis, Nieuwegein, the Netherlands.
  • van den Hoogen FHJ; Department of Dermatology, Streekziekenhuis Koningin Beatrix, Winterswijk, the Netherlands.
  • Vriezekolk JE; Department of Dermatology, Zuyderland Medisch Centrum, Sittard-Geleen, the Netherlands.
  • de Jong EMGJ; Faculty of Medical Sciences, Radboud University, Nijmegen, the Netherlands.
J Dermatolog Treat ; 35(1): 2304025, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38263716
ABSTRACT

Background:

Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment. Therefore, this study aimed to assess these impairments in patients with psoriasis who started using biologicals/small molecule inhibitors.

Methods:

Using data from the prospective BioCAPTURE registry, we collected patient, disease, and treatment parameters, as well as work/ADL impairments at baseline, 6 and 12 months. Changes in impairment parameters and correlations between impairment and patient/disease characteristics were assessed using generalized estimating equations.

Results:

We included 194 patients in our analysis. After biological initiation, disease activity decreased significantly (PASI 11.2 at baseline versus 3.9 at 12 months, p < 0.001). Work-for-pay in this cohort was lower than in the Dutch general population (53% versus 67%, p = 0.01). In patients who had work-for-pay, presenteeism improved over time (5% at baseline versus 0% at 12 months, p = 0.04). Up to half of the patients reported impairments in ADL, which did not change over time. Associations between impairments and contextual factors varied, but all impairments were associated with worse mental/physical general functioning.

Conclusion:

Patients with psoriasis using biologicals are less likely to have work-for-pay. Treatment improves the work productivity of employed patients, but we were unable to detect changes in ADL performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Actividades Cotidianas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Dermatolog Treat Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Actividades Cotidianas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Dermatolog Treat Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido