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Patterns of proliferation and fibrosis in a rat model of endometriosis following administration of Allium cepa.
Kula, Hakan; Ilgen, Orkun; Kurt, Sefa; Yilmaz, Filiz.
Afiliación
  • Kula H; Department of Obstetrics and Gynecology, Dokuz Eylul University, Izmir, Turkey.
  • Ilgen O; Department of Obstetrics and Gynecology, Dokuz Eylul University, Izmir, Turkey.
  • Kurt S; Department of Obstetrics and Gynecology, Dokuz Eylul University, Izmir, Turkey.
  • Yilmaz F; Department of Histology and Embryology, Hitit University, Corum, Turkey.
Clin Exp Reprod Med ; 51(2): 112-119, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38263589
ABSTRACT

OBJECTIVE:

Endometriosis is a common gynecological disease among reproductive-age women. Numerous hypotheses exist regarding the pathogenesis of endometriosis. In Turkey, the consumption of Allium cepa (commonly known as the "onion cure") is a popular treatment employed to alleviate a variety of gynecological disorders.

METHODS:

In this study, our objective was to assess the therapeutic mechanisms of the onion bulb A. cepa using an autologous endometriosis model in Sprague-Dawley rats. Previous research has shown that A. cepa possesses anti-inflammatory, antioxidant, and antiapoptotic properties. We evaluated the pathological condition of endometriotic implants by employing hematoxylin-eosin staining and Ki67 immunohistochemistry analysis. Transforming growth factor-beta 1 (TGF-ß1) and alpha-smooth muscle actin (α-SMA) have been identified as profibrotic markers that are highly overexpressed in endometriotic tissues relative to eutopic endometrial tissue. Furthermore, TGF-ß1 influences the differentiation and progression of endometriosis. To quantify profibrotic activity, we measured TGF-ß1 and α-SMA using the immunosorbent assay method.

RESULTS:

Lower histologic evaluation scores for endometriotic implants were observed in the group receiving high-dose A. cepa relative to the other groups. Ki67 expression was reduced following the high-dose A. cepa regimen, which consisted of 30% A. cepa and 70% normal feed. However, no statistically significant differences in TGF-ß1 or α-SMA levels were observed among the groups (p=0.7 and p=0.778, respectively).

CONCLUSION:

The findings suggest that A. cepa could serve as a therapeutic agent in endometriosis treatment, as evidenced by the reduction in proliferative potential. Nevertheless, A. cepa was not associated with significantly lower levels of endometriosis-associated TGF-ß1 or α-SMA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Clin Exp Reprod Med Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Clin Exp Reprod Med Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: