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Reference intervals of cell population data parameters in Sysmex XN-Series and its patterns of changes from early adulthood to geriatric ages in South Korea.
Choi, Yong Jun; Park, Ju-Heon; Cho, Seon; Park, Hyeran; Kim, Suyoung; Kwon, Eunjoo; Cho, Han-Ik; Nah, Eun-Hee.
Afiliación
  • Choi YJ; Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
  • Park JH; Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
  • Cho S; Health Promotion Research Institute, Korea Association of Health Promotion, Seoul, South Korea.
  • Park H; Health Promotion Research Institute, Korea Association of Health Promotion, Seoul, South Korea.
  • Kim S; Health Promotion Research Institute, Korea Association of Health Promotion, Seoul, South Korea.
  • Kwon E; Health Promotion Research Institute, Korea Association of Health Promotion, Seoul, South Korea.
  • Cho HI; MEDIcheck LAB, Korea Association of Health Promotion, Seoul, South Korea.
  • Nah EH; Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
Int J Lab Hematol ; 46(3): 466-473, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38263481
ABSTRACT

INTRODUCTION:

Cell population data (CPD) parameters may be putative biomarkers for the screening of various diseases including some infections and myelodysplastic syndrome. This study aimed to establish the age- and sex-specific reference intervals (RIs) for the CPD parameters in the Korean population.

METHODS:

The reference population for the RIs of CPD parameters comprised 124 856 subjects aged 20-99 years. CPD parameters were obtained from Sysmex XN-2000 (Kobe, Japan) datasets from 17 health promotion centers in 13 South Korean cities. We determined significant partitions for age and sex, and calculated RIs according to Clinical and Laboratory Standards Institute C28-A3 guidelines.

RESULTS:

The side scattered light intensity in the neutrophil area and the lymphocyte area did not require sex-related partitioning except in those over the age of 50, among whom the lower limit (LL) and upper limit (UL) were lower in females. However, the side scattered light distribution width in the lymphocyte area required age- and sex-related partitioning, in which LL and UL were higher in females. The LL and UL of the fluorescent light distribution width were higher in males in the neutrophil area and higher in females in the lymphocyte area, but age-related partitioning was not required. The forward scattered light intensity in the neutrophil area, lymphocyte area, and monocyte area did not require age-related partitioning in males.

CONCLUSION:

This study has determined comprehensive age- and sex-specific RIs for CPD parameters, which could help to prove the clinical significance of these parameters in the Sysmex XN-2000.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neutrófilos Tipo de estudio: Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neutrófilos Tipo de estudio: Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido