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Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor.
Yoshida, Takashi; Tashiro, Syoichi; Nagoshi, Narihito; Shinozaki, Munehisa; Shibata, Takahiro; Inoue, Mitsuhiro; Ogawa, Shoji; Shibata, Shinsuke; Tsuji, Tetsuya; Okano, Hideyuki; Nakamura, Masaya.
Afiliación
  • Yoshida T; Departments of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Tashiro S; Departments of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan nagoshi@keio.jp s-tashiro@z2.keio.jp.
  • Nagoshi N; Orthopaedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan nagoshi@keio.jp s-tashiro@z2.keio.jp.
  • Shinozaki M; Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Shibata T; Orthopaedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Inoue M; Regenerative and Cellular Medicine Kobe Center, Sumitomo Pharma, Kobe, Hyogo 650-0047, Japan.
  • Ogawa S; Formulation Research & Development Laboratories, Sumitomo Pharma, Suita, Osaka 564-0053, Japan.
  • Shibata S; Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Tsuji T; Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata-shi, Niigata 951-8510, Japan.
  • Okano H; Departments of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
  • Nakamura M; Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
eNeuro ; 11(2)2024 Feb.
Article en En | MEDLINE | ID: mdl-38262737
ABSTRACT
Spinal cord injury (SCI) often results in various long-term sequelae, and chronically injured spinal cords exhibit a refractory feature, showing a limited response to cell transplantation therapies. To our knowledge, no preclinical studies have reported a treatment approach with results surpassing those of treatment comprising rehabilitation alone. In this study of rats with SCI, we propose a novel combined therapy involving a semaphorin 3A inhibitor (Sema3Ai), which enhances axonal regeneration, as the third treatment element in combination with neural stem/progenitor cell transplantation and rehabilitation. This comprehensive therapeutic strategy achieved significant improvements in host-derived neuronal and oligodendrocyte differentiation at the SCI epicenter and promoted axonal regeneration even in the chronically injured spinal cord. The elongated axons established functional electrical connections, contributing to significant enhancements in locomotor mobility when compared with animals treated with transplantation and rehabilitation. As a result, our combined transplantation, Sema3Ai, and rehabilitation treatment have the potential to serve as a critical step forward for chronic SCI patients, improving their ability to regain motor function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Células-Madre Neurales Límite: Animals / Humans Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Células-Madre Neurales Límite: Animals / Humans Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos