Treatment approaches in autoimmune pancreatitis (Review).
Biomed Rep
; 20(2): 26, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38259589
ABSTRACT
Autoimmune pancreatitis (AIP) is a rare disease. There are two distinct types of AIP AIP type 1 (AIP-1), a pancreatic manifestation of a multi-organ disease linked to immunoglobulin (Ig)G4, and AIP type 2 (AIP-2), a pancreas-specific disease unrelated to IgG4. The usual course of treatment for AIP is oral corticosteroid medication. Rituximab has also been recommended for recurrent AIP-1 in order to initiate remission and provide ongoing treatment. Immunomodulators such as azathioprine are used to keep certain patients in remission. Evaluation also takes into account a number of pharmacological alternatives, including biologic drugs like anti-tumor necrosis factor therapy, a safe and efficient second-line treatment for AIP-2 relapse or steroid dependence. Corticosteroids and immunosuppressants, which are poorly tolerated due to considerable side effects, are being replaced by other biologic drugs, which may offer a beneficial therapeutic alternative.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Biomed Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Rumanía
Pais de publicación:
Reino Unido