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Prognostic value of neutrophil-to-lymphocyte ratio at diagnosis in colorectal cancer: propensity score analysis.
Ortiz López, David; Marchena Gómez, Joaquín; Nogués Ramia, Eva María; Sosa Quesada, Yurena; Arencibia Pérez, Beatriz; Artiles Armas, Manuel; Gil García, Julia; Roque Castellano, Cristina.
Afiliación
  • Ortiz López D; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín, España.
  • Marchena Gómez J; Cirugía General y del Aparatp Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
  • Nogués Ramia EM; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
  • Sosa Quesada Y; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
  • Arencibia Pérez B; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín, España.
  • Artiles Armas M; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
  • Gil García J; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
  • Roque Castellano C; Cirugía General y del Aparato Digestivo, Hospital Universitario de Gran Canaria Dr. Negrín.
Rev Esp Enferm Dig ; 116(8): 408-415, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38258802
ABSTRACT

INTRODUCTION:

baseline neutrophil-to-lymphocyte ratio (NLR) at the time of colorectal cancer (CRC) diagnosis has been proposed as a predictor of long-term survival. The aim of this study was to analyze its usefulness in a homogeneous population with control of the main confounding factors.

METHODOLOGY:

observational study of 836 patients who underwent surgery for CRC. Patients were divided into two groups NLR ≤ 3.3 vs NLR > 3.3. To control for confounders, they were matched one-to-one by propensity analysis. A final cohort of 526 patients was included in the study.

RESULTS:

the two groups were mismatched in terms of age, comorbidity, tumor stage, rectal location, and neoadjuvant therapy. Once matching was performed, baseline NLR was statistically significantly associated with long-term survival (p < 0.001) and behaved as an independent prognostic factor for survival (p = 0.001; HR 1.99; 95 % CI 1.32-3.00) when adjusted in a Cox regression model using age (p < 0.001; HR 1.04; 95 % CI 1.02-1.06) and the Charlson Comorbidity Index (p < 0.001; HR 1.40; 95 % CI 1.27-1.55). Neoadjuvant therapy lost its statistical significance (p = 0.137; HR 1.59; 95 % CI 0.86-2.93).

CONCLUSIONS:

a high baseline NLR (> 3.3) in patients with colorectal cancer at diagnosis represents a poor prognostic factor in terms of survival. Its use in routine practice could intensify therapeutic strategies and follow-up in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Neoplasias Colorrectales / Puntaje de Propensión / Neutrófilos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Rev Esp Enferm Dig Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Neoplasias Colorrectales / Puntaje de Propensión / Neutrófilos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Rev Esp Enferm Dig Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: España