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Multimodal non-invasive evaluation in MRI-negative epilepsy patients.
Wang, Wei; Huang, Qian; Zhou, Qilin; Han, Jiaqi; Zhang, Xiating; Li, Liping; Lin, Yicong; Wang, Yuping.
Afiliación
  • Wang W; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Huang Q; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zhou Q; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Han J; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zhang X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Li L; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Lin Y; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Wang Y; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Epilepsia Open ; 9(2): 765-775, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38258486
ABSTRACT
Presurgical evaluation is still challenging for MRI-negative epilepsy patients. As non-invasive modalities are the easiest acceptable and economic methods in determining the epileptogenic zone, we analyzed the localization value of common non-invasive methods in MRI-negative epilepsy patients. In this study, we included epilepsy patients undergoing presurgical evaluation with presurgical negative MRI. MRI post-processing was performed using a Morphometric Analysis Program (MAP) on T1-weighted volumetric MRI. The relationship between MAP, magnetoencephalography (MEG), scalp electroencephalogram (EEG), and seizure outcomes was analyzed to figure out the localization value of different non-invasive methods. Eighty-six patients were included in this study. Complete resection of the MAP-positive regions or the MEG-positive regions was positively associated with seizure freedom (p = 0.028 and 0.007, respectively). When an area is co-localized by MAP and MEG, the resection of the area was significantly associated with seizure freedom (p = 0.006). However, neither the EEG lateralization nor the EEG localization showed statistical association with the surgical outcome (p = 0.683 and 0.505, respectively). In conclusion, scalp EEG had a limited role in presurgical localization and predicting seizure outcome, combining MAP and MEG results can significantly improve the localization of epileptogenic lesions and have a positive association with seizure-free outcome. PLAIN LANGUAGE

SUMMARY:

Due to the lack of obvious structure abnormalities on neuroimaging examinations, the identification of epilepsy lesions in MRI-negative epilepsy patients can be difficult. In this study, we intended to use non-invasive examinations to explore the potential epileptic lesions in MRI-negative epilepsy patients and to determine the results accuracy by comparing the neuroimaging results with the epilepsy surgery outcomes. A total of 86 epilepsy patients without obvious structure lesions on MRI were included, and we found that the combinations of different non-invasive examinations and neuroimaging post-processing methods are significantly associated with the seizure freedom results of epilepsy surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Epilepsia Open Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Epilepsia Open Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos