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New triterpenoid saponin from the aerial part of Abrus canescens Welw ex. Bak. (Fabaceae) and their antibacterial activities.
Mahamat Djamalladine, Djamalladine; Mabou, Florence Déclaire; Feugap Tsamo, Donald Leonel; Tamokou, Jean-De-Dieu; Voutquenne-Nazabadioko, Laurence; Tsopmo, Apollinaire; Ngnokam, David.
Afiliación
  • Mahamat Djamalladine D; Research Unit of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Mabou FD; Research Unit of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Feugap Tsamo DL; Research Unit of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Tamokou JD; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Voutquenne-Nazabadioko L; Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), Reims, France.
  • Tsopmo A; Food Science, Department of Chemistry, Carleton University, Ottawa, ON, Canada.
  • Ngnokam D; Research Unit of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Nat Prod Res ; : 1-12, 2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38258449
ABSTRACT
The chemical investigation of the aerial part of Abrus canescens led to isolation of a new triterpenoid glycoside named Canescensoside (1) and four known compounds including longispinogenin-3-O-ß-D-glucuronopyranoside (2), ß-sitosterol-3-O-ß-D-glucoside (3), apigenin-7-O-ß-D-glucopyranoside (4) and apigenin-7-O-[α-L-rhamnopyranosyl-(1→3)-ß-D-glucopyranoside] (5). Structures of compounds were assigned by interpretation of their spectral data, mainly 1D and 2D NMR, HRESIMS, and by comparison with the reported data. The MeOH extract, EtOAc and n-BuOH fractions as well as isolated compounds were tested for their antibacterial activities against four bacteria strains among which, two Gram-negative (Pseudomonas aeruginosa ATCC 76110 and Escherichia coli ATCC 8739) and two Gram-positive (Enterococcus faecalis ATCC 29212 and Staphylococcus aureus ATCC 25923) bacteria using the broth microdilution method. The MeOH extract and EtOAc fraction exhibited significant activities (MIC values ranging from 128 to 512 µg/mL) against all the tested bacteria. Compounds 2 and 3 showed the lowest MIC values of 55.47 and 50.40 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido