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Serologic and Genomic Investigation of West Nile Virus in Kosovo.
Emmerich, Petra; Jakupi, Xhevat; Sherifi, Kurtesh; Dreshaj, Shemsedin; Kalaveshi, Ariana; Hemmer, Christoph; Hajdari, Donjeta Pllana; von Possel, Ronald; Cadar, Dániel; Tomazatos, Alexandru.
Afiliación
  • Emmerich P; Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
  • Jakupi X; Department of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, University of Rostock, 18057 Rostock, Germany.
  • Sherifi K; National Institute of Public Health of Kosovo, 10000 Pristina, Kosovo.
  • Dreshaj S; Faculty of Agriculture and Veterinary, University of Prishtina "Hasan Prishtina", 10000 Prishtina, Kosovo.
  • Kalaveshi A; University Clinic of Infectious Diseases, Faculty of Medicine, University of Pristina, 10000 Pristina, Kosovo.
  • Hemmer C; National Institute of Public Health of Kosovo, 10000 Pristina, Kosovo.
  • Hajdari DP; Department of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, University of Rostock, 18057 Rostock, Germany.
  • von Possel R; National Institute of Public Health of Kosovo, 10000 Pristina, Kosovo.
  • Cadar D; Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.
  • Tomazatos A; Department of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, University of Rostock, 18057 Rostock, Germany.
Viruses ; 16(1)2023 12 30.
Article en En | MEDLINE | ID: mdl-38257766
ABSTRACT
The prevalence of West Nile virus (WNV) is increasing across Europe, with cases emerging in previously unaffected countries. Kosovo is situated in a WNV-endemic region where the seroepidemiological data on WNV in humans remains absent. To address this issue, we have conducted a seroepidemiological investigation of 453 randomly selected sera from a hospital in Kosovo, revealing a 1.55% anti-WNV IgG seroprevalence. Comparative and phylogeographic analyses of the WNV genomes obtained by sequencing archived samples from patients with West Nile fever indicate at least two recent and distinct introductions of WNV lineage 2 into Kosovo from neighboring countries. These findings confirm the eco-epidemiological status of WNV in southeast Europe, where long- and short-range dispersion of lineage 2 strains contributes to a wider circulation via central Europe. Our results suggest an increasing risk for WNV spreading in Kosovo, underscoring the need for an integrated national surveillance program targeting vectors and avian populations for early epidemic detection, as well as the screening of blood donors to gauge the impact of virus circulation on the human population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre del Nilo Occidental / Virus del Nilo Occidental Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre del Nilo Occidental / Virus del Nilo Occidental Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza