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Juniperus oxycedrus L. ssp. Essential Oil Microneedles: A Promising Antimicrobial and Wound Healing Activity.
Battah, Basem; Shbibe, Lama; Ahmad, Osama; Soukkarieh, Chadi; Al Okla, Souad Mahmoud; Chianese, Teresa; Rosati, Luigi; Vora, Lalitkumar K; Zhao, Li; Marrazzo, Alessandra; Ferrari, Marco; Li, Linlin; Donnelly, Ryan F; Zanetti, Stefania; Mazzarello, Vittorio; Donadu, Matthew Gavino.
Afiliación
  • Battah B; Department of Biochemistry and Microbiology, Faculty of Pharmacy, Antioch Syrian Private University, Maaret Saidnaya 22734, Syria.
  • Shbibe L; Faculty of Science, Damascus University, Damascus P.O. Box 30621, Syria.
  • Ahmad O; Faculty of Medicine, Syrian Private University (SPU), Daraa International Highway, Damascus 36822, Syria.
  • Soukkarieh C; Faculty of Medicine, Kalamoon University, Damascus 222, Syria.
  • Al Okla SM; Faculty of Science, Damascus University, Damascus P.O. Box 30621, Syria.
  • Chianese T; College of Medicine and Health Sciences, National University of Science, Sohar 321, Oman.
  • Rosati L; Department of Biology, University Federico II, Via Cintia 21, 80126 Napoli, Italy.
  • Vora LK; Department of Biology, University Federico II, Via Cintia 21, 80126 Napoli, Italy.
  • Zhao L; Medical Biology Centre, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Marrazzo A; Medical Biology Centre, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Ferrari M; Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy.
  • Li L; Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137 Trieste, Italy.
  • Donnelly RF; Medical Biology Centre, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Zanetti S; Medical Biology Centre, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Mazzarello V; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Donadu MG; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Pharmaceuticals (Basel) ; 17(1)2023 Dec 27.
Article en En | MEDLINE | ID: mdl-38256874
ABSTRACT
The use of essential oil (EO) in treating infected wounds is still challenging. A lot of effort has been made to make such an application more convenient. Recently, microneedles (MNDs) have been considered as a smart dermal delivery system to overcome the poor absorption and distribution, low bioavailability, and skin penetration of some drugs. The aim of our study is to evaluate the wound healing activity of juniper-EO-loaded MNDs (EO MNDs) against wounds with bacterial and fungal infection. The Polyvinylpyrrolidone (PVP) MNDs were prepared using the gel-filled mold technique and loaded with juniper EO. In vivo models were created and wounds on rats were infected with two clinically isolated bacterial strains Pseudomonas aeruginosa and Staphylococcus aureus. Furthermore, Candida albicans was used to mimic fungal infection and juniper EO MNDs were tested. The obtained results showed an improvement in wound healing which started from the third day after application of the juniper EO MNDs, and at the sixth day post-infection, the treated wounds were significantly smaller than untreated wounds. A complete healing was shown by the 12th day after infection. Furthermore, our cytotoxicity results showed a cytotoxic effect of juniper EO MNDs on epithelial cells, which explained the faster wound healing in rats. Our study showed that juniper EO MNDs represent a novel strategy in EO delivery with minimal invasion. Juniper EO MNDs demonstrated significant antimicrobial activity against both the bacterial strains Pseudomonas aeruginosa and Staphylococcus aureus and against one fungal strain, Candida albicans. Finally, application of juniper EO MNDs exerted promising activity in the treatment and healing of wound infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Siria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Siria Pais de publicación: Suiza