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Role of Elevated Serum TGF-ß1 and the Common Promoter TGFB1-509C/T Polymorphism in the Development and Progression of Primary Glial Tumors and Brain Metastases.
Aleksandrova, Elina; Mindov, Ivan; Petrov, Bozhidar; Dimitrova, Ivelina; Petrov, Nikolay; Ananiev, Julian; Vlaykova, Tatyana; Valkanov, Stefan.
Afiliación
  • Aleksandrova E; Department of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Mindov I; Department of Surgery, Neurosurgery, Urology and Anaesthesiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Petrov B; Department of Surgery, Neurosurgery, Urology and Anaesthesiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Dimitrova I; Department of Surgery, Neurosurgery, Urology and Anaesthesiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Petrov N; Department of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Ananiev J; Department of General and Clinical Pathology, Forensic Medicine, Deontology and Dermatovenerology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Vlaykova T; Department of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
  • Valkanov S; Department of Surgery, Neurosurgery, Urology and Anaesthesiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
Medicina (Kaunas) ; 60(1)2024 Jan 13.
Article en En | MEDLINE | ID: mdl-38256406
ABSTRACT
Background and

Objectives:

The role of transforming growth factor-beta1 (TGF-ß1) has been widely studied in the context of carcinogenesis. It has been involved in the pathogenesis of primary brain tumors or brain metastases due to its pleiotropic effects on immune regulation and tissue homeostasis. In line with recent findings, the aim of the current study was to examine the role of circulating TGF-ß1 and the -509C/T functional polymorphism (rs1800469) in the TGFB1 gene promoter in the susceptibility and progression of primary brain tumors and brain metastases among patients from the Bulgarian population. Materials and

Methods:

Cases with a confirmed diagnosis were genotyped by the polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Serum TGF-ß1 levels were determined by ELISA. Immunohistochemical evaluation of the expression of TGF-ß1 and the TGF-ß1 receptor-type II was conducted.

Results:

We observed that TGF-ß1 serum levels correlate with the genotype and are sex-related. TGF-ß1 serum levels were significantly elevated in patients compared to controls. Additionally, the T/T-genotype determined higher circulating levels of the cytokine. The same genotype determined the shorter median survival after surgery for the patients. The immunohistochemical analysis revealed a statistical tendency cases expressing TGF-ß1 in the cytoplasm had elevated levels of the cytokine in the serum compared to the negative cases.

Conclusions:

Overall, our results indicate a negative effect of the T-allele on the predisposition and prognosis of brain malignancies, and the genetically determined higher TGF-ß1 serum levels might contribute to the worse prognosis and metastatic capacity of brain malignancies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Bulgaria Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Bulgaria Pais de publicación: Suiza