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Expression Pattern and Prognostic Significance of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 in Chronic Lymphocytic Leukemia.
Tomic Vujovic, Kristina; Ugrin, Milena; Tosic, Natasa; Vukovic, Vojin; Marjanovic, Irena; Kostic, Tatjana; Stankovic, Sanja; Otasevic, Vladimir; Sarac, Sofija; Antic, Darko; Pavlovic, Sonja; Karan-Djurasevic, Teodora.
Afiliación
  • Tomic Vujovic K; Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Ugrin M; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11042 Belgrade, Serbia.
  • Tosic N; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11042 Belgrade, Serbia.
  • Vukovic V; Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Marjanovic I; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11042 Belgrade, Serbia.
  • Kostic T; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11042 Belgrade, Serbia.
  • Stankovic S; Center for Medical Biochemistry, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Otasevic V; Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
  • Sarac S; Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Antic D; Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Pavlovic S; Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  • Karan-Djurasevic T; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Int J Mol Sci ; 25(2)2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38255996
ABSTRACT
Dysregulated expression of the long non-coding RNA MALAT1 has been implicated in the pathogenesis and progression of a variety of cancers, including hematological malignancies, but it has been poorly investigated in chronic lymphocytic leukemia (CLL). In this study, the expression of MALAT1 was measured using a quantitative reverse-transcriptase polymerase chain reaction in the peripheral blood mononuclear cells of 114 unselected, newly diagnosed CLL patients in order to analyze its association with clinical, laboratory, and molecular patients' characteristics at diagnosis, as well as its prognostic relevance. MALAT1 was found to be upregulated in CLL patients in comparison to healthy controls, and expression levels were not related to age, leukocyte, lymphocyte and platelet count, serum ß2-microglobulin, and IGHV somatic hypermutational status. On the other hand, high MALAT1 expression was associated with several favorable prognostic markers (high hemoglobin, low serum lactate dehydrogenase, earlier clinical stages, CD38-negative status), but also with unfavorable cytogenetics. Furthermore, an association between high MALAT1 levels and longer time to first treatment and overall survival in IGHV-unmutated CLL subtype was observed. In summary, our results imply that high MALAT1 expression at diagnosis may be a predictor of better prognosis and point to MALAT1 expression profiling as a candidate biomarker potentially useful in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Neoplasias Hematológicas / ARN Largo no Codificante Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Neoplasias Hematológicas / ARN Largo no Codificante Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Suiza