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Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk.
Kristof, Zsuliet; Gal, Zsofia; Torok, Dora; Eszlari, Nora; Sutori, Sara; Sperlagh, Beata; Anderson, Ian M; Deakin, Bill; Bagdy, Gyorgy; Juhasz, Gabriella; Gonda, Xenia.
Afiliación
  • Kristof Z; Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa utca 6, 1082 Budapest, Hungary.
  • Gal Z; Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine, Szigony utca 43, 1083 Budapest, Hungary.
  • Torok D; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary.
  • Eszlari N; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary.
  • Sutori S; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary.
  • Sperlagh B; NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary.
  • Anderson IM; National Centre for Suicide Research and Prevention (NASP), Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Granits väg 4, 17165 Solna, Sweden.
  • Deakin B; Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine, Szigony utca 43, 1083 Budapest, Hungary.
  • Bagdy G; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre, 46 Grafton Street, Manchester M13 9NT, UK.
  • Juhasz G; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre, 46 Grafton Street, Manchester M13 9NT, UK.
  • Gonda X; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, 1089 Budapest, Hungary.
Int J Mol Sci ; 25(2)2024 Jan 10.
Article en En | MEDLINE | ID: mdl-38255938
ABSTRACT
Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors on lifetime suicide attempts and current suicide risk markers. Overall, 1644 participants completed questionnaires assessing childhood adversities, recent negative life events, and provided information about previous suicide attempts and current suicide risk-related markers, including thoughts of ending their life, death, and hopelessness. Subjects were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into logistic and linear regression models, followed by a clumping procedure to identify clumps of SNPs with a significant main and interaction effect. We identified two significant clumps with a main effect on current suicidal ideation with top SNPs rs641940 and rs1653613. In interaction with childhood trauma, we identified a clump with top SNP psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP. Our results suggest that P2RX7 variation may mediate the effect of early childhood adversities and traumas on later emergence of suicide risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Purinérgicos P2X7 / Experiencias Adversas de la Infancia / Enfermedades Neuroinflamatorias Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Child, preschool / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Purinérgicos P2X7 / Experiencias Adversas de la Infancia / Enfermedades Neuroinflamatorias Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Child, preschool / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza