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Serum Anti-Zta and Anti-LMP1 Antibodies in Oropharyngeal Cancer Related to Epstein-Barr Virus-Diagnostic Usefulness.
Polz, Anna; Morshed, Kamal; Drop, Bartlomiej; Drop, Andrzej; Polz-Dacewicz, Malgorzata.
Afiliación
  • Polz A; Genomed S.A., 02-971 Warsaw, Poland.
  • Morshed K; Department of Otolaryngology Head and Neck Cancer, University of Technology and Humanities in Radom, 26-600 Radom, Poland.
  • Drop B; Department of Computer Science and Medical Statistics with the e-Health Laboratory, 20-090 Lublin, Poland.
  • Drop A; 1st Department of Medical Radiology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Polz-Dacewicz M; Department of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.
Cancers (Basel) ; 16(2)2024 Jan 13.
Article en En | MEDLINE | ID: mdl-38254830
ABSTRACT

BACKGROUND:

The role of the Epstein-Barr virus (EBV), the first known human oncogenic virus, in the development of nasopharyngeal cancer (NPC) is already well documented. There are few studies in the available scientific literature on oropharyngeal cancer associated with EBV infection. Due to the lack of an effective vaccine against EBV, it is necessary to search for new markers for the early diagnosis and prognosis of this disease. The aim of current study was to determine the usefulness of anti-Zta and anti-LMP1 antibodies as diagnostic and prognostic markers in EBV positive OPSCC patients.

METHODS:

For this purpose, experiments were carried out to determine both the prevalence and level of EBVCA, EBNA1, EA, Zta, and LMP1 antibodies in serum patients depending on histological differentiation-grading and TNM classification (ELISA assay).

RESULTS:

Based on the obtained results, we showed that OPSCC EBV positive patients are characterized by a higher level of anti-Zta antibodies than in the EBV negative group. Their level depended on the clinical stage. Moreover, a ROC analysis confirmed the diagnostic accuracy of anti-Zta antibodies.

CONCLUSIONS:

Anti-Zta and anti-LMP1 antibodies may be useful in the diagnosis of OPSCC. It seems that combined antibody testing should be performed to increase diagnostic accuracy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza