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An analysis of differences in Carbapenem-resistant Enterobacterales in different regions: a multicenter cross-sectional study.
Guo, Bo; Li, Peili; Qin, Bingyu; Wang, Shanmei; Zhang, Wenxiao; Shi, Yuan; Yang, Jianxu; Niu, Jingjing; Chen, Shifeng; Chen, Xiao; Cui, Lin; Fu, Qizhi; Guo, Lin; Hou, Zhe; Li, Hua; Li, Xiaohui; Liu, Ruifang; Liu, Xiaojun; Mao, Zhengrong; Niu, Xingguo; Qin, Chao; Song, Xianrong; Sun, Rongqing; Sun, Tongwen; Wang, Daoxie; Wang, Yong; Xu, Lanjuan; Xu, Xin; Yang, Yuejie; Zhang, Baoquan; Zhou, Dongmin; Li, Zhaozhen; Chen, Yinyin; Jin, Yue; Du, Juan; Shao, Huanzhang.
Afiliación
  • Guo B; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Li P; Department of Public Utilities Development, Henan Provincial People's Hospital, Zhengzhou, China.
  • Qin B; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Wang S; Department of Microbiology Laboratory, Henan Provincial People's Hospital, Zhengzhou, China.
  • Zhang W; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Shi Y; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Yang J; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Niu J; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Chen S; Department of Critical Care Medicine, The Second People's Hospital of Pingdingshan City, Pingdingshan, China.
  • Chen X; Department of Critical Care Medicine, Nanyang Nanshi Hospital, Nanyang, China.
  • Cui L; Department of Critical Care Medicine, Yellow River Central Hospital, Zhengzhou, China.
  • Fu Q; Department of Critical Care Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
  • Guo L; Department of Critical Care Medicine, The Seventh People's Hospital of Zhengzhou, Zhengzhou, China.
  • Hou Z; Department of Critical Care Medicine, Zhengzhou Orthopedic Hospital, Zhengzhou, China.
  • Li H; Department of Critical Care Medicine, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China.
  • Li X; Department of Critical Care Medicine, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.
  • Liu R; Department of Critical Care Medicine, The Third People's Hospital of Henan Province, Zhengzhou, China.
  • Liu X; Department of Critical Care Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Mao Z; Department of Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
  • Niu X; Department of Critical Care Medicine, Zhengzhou People's Hospital, Zhengzhou, 450000, China.
  • Qin C; Department of Critical Care Medicine, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Song X; Department of Critical Care Medicine, Henan Provincial Chest Hospital, Zhengzhou, China.
  • Sun R; Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Sun T; Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Wang D; Department of Critical Care Medicine, The Third People's Hospital of Zhengzhou, Zhengzhou, China.
  • Wang Y; Department of Critical Care Medicine, Huaihe Hospital of Henan University, Kaifeng, China.
  • Xu L; Department of Critical Care Medicine, Zhengzhou Central Hospital, Zhengzhou, China.
  • Xu X; Department of Critical Care Medicine, The First Affiliated Hospital of Henan University, Kaifeng, China.
  • Yang Y; Department of Critical Care Medicine, The Sixth People's Hospital of Zhengzhou, Zhengzhou, China.
  • Zhang B; Department of Critical Care Medicine, The Third Affiliated Hospital of Xinxiang Medical College, Xinxiang, China.
  • Zhou D; Department of Critical Care Medicine, Henan Cancer Hospital, Zhengzhou, China.
  • Li Z; Department of Critical Care Medicine, Henan Provincial Chest Hospital, Zhengzhou, China.
  • Chen Y; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Jin Y; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Du J; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China.
  • Shao H; Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China. shaohuanzhang001@
BMC Infect Dis ; 24(1): 116, 2024 Jan 22.
Article en En | MEDLINE | ID: mdl-38254025
ABSTRACT

OBJECTIVE:

This study aimed to explore the characteristics of carbapenem-resistant Enterobacterales (CRE) patients in the intensive care unit (ICU) in different regions of Henan Province to provide evidence for the targeted prevention and treatment of CRE.

METHODS:

This was a cross-sectional study. CRE screening was conducted in the ICUs of 78 hospitals in Henan Province, China, on March 10, 2021. The patients were divided into provincial capital hospitals and nonprovincial capital hospitals for comparative analysis.

RESULTS:

This study involved 1009 patients in total, of whom 241 were CRE-positive patients, 92 were in the provincial capital hospital and 149 were in the nonprovincial capital hospital. Provincial capital hospitals had a higher rate of CRE positivity, and there was a significant difference in the rate of CRE positivity between the two groups. The body temperature; immunosuppressed state; transfer from the ICU to other hospitals; and use of enemas, arterial catheters, carbapenems, or tigecycline at the provincial capital hospital were greater than those at the nonprovincial capital hospital (P < 0.05). However, there was no significant difference in the distribution of carbapenemase strains or enzymes between the two groups.

CONCLUSIONS:

The detection rate of CRE was significantly greater in provincial capital hospitals than in nonprovincial capital hospitals. The source of the patients, invasive procedures, and use of advanced antibiotics may account for the differences. Carbapenem-resistant Klebsiella pneumoniae (CR-KPN) was the most prevalent strain. Klebsiella pneumoniae carbapenemase (KPC) was the predominant carbapenemase enzyme. The distributions of carbapenemase strains and enzymes were similar in different regions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura Corporal / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura Corporal / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido