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The weakened physiological functions of human serum albumin in presence of polystyrene nanoplastics.
Wang, Yaoyao; Li, Haimei; Lan, Jing; Guan, Rui; Bao, Yan; Du, Xianfa; Zhao, Zongshan; Shi, Rongguang; Hollert, Henner; Zhao, Xingchen.
Afiliación
  • Wang Y; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Li H; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Lan J; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China. Electronic address: lanjing@qdu.edu.cn.
  • Guan R; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Bao Y; Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
  • Du X; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China; Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
  • Zhao Z; College of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China.
  • Shi R; Ministry of Agriculture and Rural Affairs, Agro-Environmental Protection Institute, No. 31 Fukang Road, Nankai District, 300191 Tianjin, China.
  • Hollert H; Department for Evolutionary Ecology and Environmental Toxicology, Goethe University, Frankfurt am Main 60438, Germany.
  • Zhao X; Department for Evolutionary Ecology and Environmental Toxicology, Goethe University, Frankfurt am Main 60438, Germany.
Int J Biol Macromol ; 261(Pt 2): 129609, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38253152
ABSTRACT
Due to the widespread presence of nanoplastics (NPs) in daily essentials and drinking water, the potential adverse effects of NPs on human health have become a global concern. Human serum albumin (HSA), the most abundant and multi-functional protein in plasma, has been chosen to understand the biological effects of NPs after entering the blood. The esterase activity and the transport of bisphenol A in the presence of polystyrene nanoplastics (PSNPs) under physiological conditions (pH 4.0 and 7.4) have been investigated to evaluate the possible biological effects. The interactions between PSNPs and HSA have also been systematically studied by multispectral methods and dynamic light scattering techniques. The esterase activity of HSA presented a decreased trend with increasing PSNPs; conversely, higher permeabilities are accompanied by higher amounts of PSNPs. Compared with the unchanged hydrodynamic diameter and weaker interactions at pH 7.4, stronger binding between HSA and PSNPs at pH 4.0 led to a significant increase in the particle size of the PSNPs-HSA complex. The quenching mechanism belonged to the static quenching type. The electrostatic force is proposed to be the dominant factor for PSNPs binding to HSA. The work provides some information about the toxicity of NPs when exposed to humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliestirenos / Albúmina Sérica Humana Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliestirenos / Albúmina Sérica Humana Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos