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Oral Cannabidiol Treatment Is Associated with an Anti-Inflammatory Gene Expression Signature in Myeloid Cells of People Living with HIV.
Marini, Simone; Huber, Amanda; Cash, Melanie N; Salemi, Marco; Cook, Robert L; Borsa, Paul; Mavian, Carla N.
Afiliación
  • Marini S; Department of Epidemiology, University of Florida, Gainesville, Florida, USA.
  • Huber A; Department of Pathology, University of Florida, Gainesville, Florida, USA.
  • Cash MN; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
  • Salemi M; Department of Pathology, University of Florida, Gainesville, Florida, USA.
  • Cook RL; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
  • Borsa P; Department of Pathology, University of Florida, Gainesville, Florida, USA.
  • Mavian CN; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Cannabis Cannabinoid Res ; 9(4): 1028-1037, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38252549
ABSTRACT

Introduction:

HIV-related comorbidities appear to be related to chronic inflammation, a condition characterizing people living with HIV (PLWH). Prior work indicates that cannabidiol (CBD) might reduce inflammation; however, the genetics underpinning of this effect are not well investigated. Our main objective is to detect gene expression alterations in human peripheral blood mononuclear cells (PBMCs) from PLWH after at least 1 month of CBD treatment. Materials and

Methods:

We analyzed ∼41,000 PBMCs from three PLWH at baseline and after CBD treatment (27-60 days) through single-cell RNA sequencing.

Results:

We obtained a coherent signature, characterized by an anti-inflammatory activity, of differentially expressed genes in myeloid cells.

Conclusions:

Our study shows how CBD is associated with alterations of gene expression in myeloid cells after CBD treatment. Clinical Trial Registration NCT05209867.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Infecciones por VIH / Células Mieloides Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cannabis Cannabinoid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Infecciones por VIH / Células Mieloides Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cannabis Cannabinoid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos