I&#954;B kinase thwarts aggregation: Phosphorylating TDP-43 for degradation.

Yang, Cha; Liu, Yanru; Hu, Fenghua

IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation.

Yang, Cha; Liu, Yanru; Hu, Fenghua.

Afiliación

Yang C; Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
Liu Y; Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
Hu F; Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.

J Cell Biol ; 223(2)2024 02 05.

Article en En | MEDLINE | ID: mdl-38252412

ABSTRACT

ABSTRACT

TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https//doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between inflammation and TDP-43 homeostasis.

Asunto(s)

Proteínas de Unión al ADN; Quinasa I-kappa B; Complejo de la Endopetidasa Proteasomal; Humanos; Citoplasma; Proteínas de Unión al ADN/química; Quinasa I-kappa B/metabolismo; Inflamación; Fosforilación; Complejo de la Endopetidasa Proteasomal/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo de la Endopetidasa Proteasomal / Proteínas de Unión al ADN / Quinasa I-kappa B Límite: Humans Idioma: En Revista: J Cell Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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