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RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques.
Wang, Shixia; Guirakhoo, Farshad; Periasamy, Sivakumar; Ryan, Valorie; Wiggins, Jonathan; Subramani, Chandru; Thibodeaux, Brett; Sahni, Jaya; Hellerstein, Michael; Kuzmina, Natalia A; Bukreyev, Alexander; Dodart, Jean-Cosme; Rumyantsev, Alexander.
Afiliación
  • Wang S; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Guirakhoo F; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Periasamy S; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA.
  • Ryan V; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Wiggins J; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Subramani C; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Thibodeaux B; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA.
  • Sahni J; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Hellerstein M; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Kuzmina NA; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Bukreyev A; Vaxxinity, Inc., Merritt Island, FL 32953, USA.
  • Dodart JC; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA.
  • Rumyantsev A; Galveston National Laboratory, Galveston, TX 77550, USA.
Vaccines (Basel) ; 12(1)2023 Dec 29.
Article en En | MEDLINE | ID: mdl-38250853
ABSTRACT
Antibodies provide critical protective immunity against COVID-19, and the Fc-mediated effector functions and mucosal antibodies also contribute to the protection. To expand the characterization of humoral immunity stimulated by subunit protein-peptide COVID-19 vaccine UB-612, preclinical studies in non-human primates were undertaken to investigate mucosal secretion and the effector functionality of vaccine-induced antibodies in antibody-dependent monocyte phagocytosis (ADMP) and antibody-dependent NK cell activation (ADNKA) assays. In cynomolgus macaques, UB-612 induced potent serum-neutralizing, RBD-specific IgG binding, ACE2 binding-inhibition antibodies, and antibodies with Fc-mediated effector functions in ADMP and ADNKA assays. Additionally, immunized animals developed mucosal antibodies in bronchoalveolar lavage fluids (BAL). The level of mucosal or serum ADMP and ADNKA antibodies was found to be UB-612 dose-dependent. Our results highlight that the novel subunit UB-612 vaccine is a potent B-cell immunogen inducing polyfunctional antibody responses contributing to anti-viral immunity and vaccine efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza