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Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing.
Foroozandeh, Amin; Shakiba, Mohamadreza; Zamani, Amirhosein; Tajiki, Alireza; Sheikhi, Mehdi; Pourmadadi, Mehrab; Pahnavar, Zohreh; Rahmani, Erfan; Aghababaei, Nafiseh; Amoli, Hossein Salar; Abdouss, Majid.
Afiliación
  • Foroozandeh A; Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
  • Shakiba M; Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
  • Zamani A; Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
  • Tajiki A; Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
  • Sheikhi M; Polymer Chemistry Research Laboratory, Department of Chemistry, University of Isfahan, Isfahan, Iran.
  • Pourmadadi M; Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
  • Pahnavar Z; Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
  • Rahmani E; Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
  • Aghababaei N; Department of Chemical Engineering, Tafresh University, Tafresh, Iran.
  • Amoli HS; Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
  • Abdouss M; Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
J Biomed Mater Res B Appl Biomater ; 112(1): e35370, 2024 01.
Article en En | MEDLINE | ID: mdl-38247254
ABSTRACT
Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility and stimulate the growth and proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low-cost polymer with good compatibility with human tissues and high mechanical stability. In this study, HA and CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing. N6/HA/CS nanofibrous composite mats were developed using a simple one-step electrospinning technique at different CS concentrations of 1, 2, and 3 wt%. The results demonstrated that incorporating HA and CS into N6 resulted in increased hydrophilicity, as well as favorable physical and mechanical properties. In addition, the minimum inhibitory concentration and (MIC) optical density techniques were used to determine the antibacterial properties of N6/HA/CS nanofibrous composite mats, and the results demonstrated that the composites could markedly inhibit the growth of Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli. Because of its superior mechanical properties, substantial antimicrobial effects, and hydrophilic surface, N6/HA/CS at 2 wt% of CS (N6/HA/CS2) was chosen as the most suitable nanofibrous mat. The swelling, porosity, gel content, and in vitro degradation studies imply that N6/HA/CS2 nanofibrous composite mat has proper moisture retention and biodegradability. Furthermore, the N6/HA/CS2 nanofibrous composite mat was discovered to be nontoxic to L929 fibroblast cells and to even improve cell proliferation. Based on the findings, this research offers a simple and rapid method for creating material that could be utilized as prospective wound dressings in clinical environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caprolactama / Quitosano / Nanofibras Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caprolactama / Quitosano / Nanofibras Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos