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Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study.
Campos-Sánchez, Irene; Navarrete-Muñoz, Eva María; Hurtado-Pomares, Miriam; Júlvez, Jordi; Lertxundi, Nerea; Martens, Dries S; Fernández-Somoano, Ana; Riaño-Galán, Isolina; Guxens, Mònica; Ibarluzea, Jesús María; Nawrot, Tim; Valera-Gran, Desirée.
Afiliación
  • Campos-Sánchez I; Department of Surgery and Pathology, Miguel Hernandez University, Alicante, Spain.
  • Navarrete-Muñoz EM; Department of Surgery and Pathology, Miguel Hernandez University, Alicante, Spain. enavarrete@umh.es.
  • Hurtado-Pomares M; Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernandez University, Alicante, Spain. enavarrete@umh.es.
  • Júlvez J; Alicante Institute for Health and Biomedical Research, Alicante, Spain. enavarrete@umh.es.
  • Lertxundi N; Department of Surgery and Pathology, Miguel Hernandez University, Alicante, Spain.
  • Martens DS; Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernandez University, Alicante, Spain.
  • Fernández-Somoano A; Clinical and Epidemiological Neuroscience (NeuroÈpia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
  • Riaño-Galán I; ISGlobal, Barcelona, Spain.
  • Guxens M; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Ibarluzea JM; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Nawrot T; Environmental Epidemiology and Child Development Group, Biodonostia Health Research Institute, San Sebastian, Spain.
  • Valera-Gran D; School of Psychology, University of the Basque Country, UPV/EHU, San Sebastián, Spain.
Eur Child Adolesc Psychiatry ; 33(8): 2803-2812, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38246982
ABSTRACT
Shortened telomere length (TL) has been associated with lower cognitive performance, different neurological diseases in adults, and certain neurodevelopmental disorders in children. However, the evidence about the association between TL and neuropsychological developmental outcomes in children from the general population is scarce. Therefore, this study aimed to explore the association between TL and neuropsychological function in children 4-5 years of age. We included 686 children from the INMA Project, a population-based birth cohort in Spain. Leucocyte TL was determined by quantitative PCR method, and neuropsychological outcomes were measured using the McCarthy Scales of Children's Abilities (MCSA). Multiple linear regression models were used to estimate associations adjusted for potential confounding variables. Main findings showed that a longer TL was associated with a higher mean working memory score (ß = 4.55; 95% CI = 0.39, 8.71). In addition, longer TL was associated with a higher mean global quantitative score (ß = 3.85; 95% CI = -0.19, 7.89), although the association was marginally significant. To our knowledge, this is the first study that shows a positive association between TL and better neuropsychological outcomes in children. Although further research is required to confirm these results, this study supports the hypothesis that TL is essential in protecting and maintaining a child's health, including cognitive functions such as working memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Neuropsicológicas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Neuropsicológicas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania