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Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism.
Wall, Carla A; Shic, Frederick; Will, Elizabeth A; Wang, Quan; Roberts, Jane E.
Afiliación
  • Wall CA; Duke University Medical Center, Center for Autism and Brain Development, 2424 Erwin Road, Suite 501, Durham, NC, 27705, USA. carla.wall@duke.edu.
  • Shic F; Seattle Children's Research Institute, Center for Child Health, Behavior and Development, 1920 Terry Ave CURE-3, Seattle, WA, 98101, USA.
  • Will EA; Department of Pediatrics, University of Washington School of Medicine, 1920 Terry Ave CURE-3, Seattle, WA, 98101, USA.
  • Wang Q; Department of Communication Sciences and Disorders, University of South Carolina, Arnold School of Public Health, 6311 Garners Ferry Road, Columbia, SC, 29209, USA.
  • Roberts JE; Key Laboratory of Spectral Imaging Technology, Xi'an Institute of Optics and Precision Mechanics of the Chinese Academy of Sciences, Xi'an, 710119, China.
J Autism Dev Disord ; 2024 Jan 21.
Article en En | MEDLINE | ID: mdl-38246961
ABSTRACT

PURPOSE:

Fragile X syndrome (FXS) is a single-gene disorder characterized by moderate to severe cognitive impairment and a high association with autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). Atypical visual attention is a feature of FXS, ASD, and ADHD. Thus, studying early attentional patterns in young children with FXS can offer insight into early emerging neurocognitive processes underlying challenges and contribute to our understanding of common and unique features of ASD and ADHD in FXS.

METHODS:

The present study examined visual attention indexed by the gap-overlap paradigm in children with FXS (n = 39) compared to children with ASD matched on intellectual ability and age (n = 40) and age-matched neurotypical controls (n = 34). The relationship between gap-overlap performance and intellectual ability, ASD, and ADHD across groups was characterized. Saccadic reaction times (RT) were collected across baseline, gap, and overlap conditions.

RESULTS:

Results indicate no group differences in RT for any conditions. However, RT of the ASD and NT groups became slower throughout the experiment whereas RT of the FXS group did not change, suggesting difficulties in habituation for the FXS group. There was no relationship between RT and intellectual ability, ADHD, or ASD symptoms in the FXS and ASD groups. In the NT group, slower RT was related to elevated ADHD symptoms only.

CONCLUSION:

Taken together, findings suggest that the social attention differences documented in FXS and ASD may be due to other cognitive factors, such as reward or motivation, rather than oculomotor control of visual attention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Autism Dev Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Autism Dev Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos